The Effectiveness of a Low Molecular Weight Heparinoid in Chronic Intermittent Haemodialysis

Ch P Henny; H ten Cate; S Surachno; P Stevens; H R Büller; M den Hartog; J W ten Cate

doi:10.1055/s-0038-1657872

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 54(02): 460-462
DOI: 10.1055/s-0038-1657872

Original Article

Schattauer GmbH Stuttgart

The Effectiveness of a Low Molecular Weight Heparinoid in Chronic Intermittent Haemodialysis

Ch P Henny

^*The Department of Haematology, Division of Haemostasis and Thrombosis, Amsterdam, The Netherlands

,

H ten Cate

^*The Department of Haematology, Division of Haemostasis and Thrombosis, Amsterdam, The Netherlands

,

S Surachno

^*The Department of Haematology, Division of Haemostasis and Thrombosis, Amsterdam, The Netherlands

,

P Stevens

^**Department of Internal Medicine, Division of Nephrology and the Amsterdam Haemodialysis Center “Diatel”, Amsterdam, The Netherlands

,

H R Büller

^*The Department of Haematology, Division of Haemostasis and Thrombosis, Amsterdam, The Netherlands

,

M den Hartog

^*The Department of Haematology, Division of Haemostasis and Thrombosis, Amsterdam, The Netherlands

,

J W ten Cate

^*The Department of Haematology, Division of Haemostasis and Thrombosis, Amsterdam, The Netherlands

› Author Affiliations

Abstract

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Summary

A new low molecular weight heparinoid, Org 10172 was compared to heparin in a randomized single blind cross-over study in 55 patients with end-stage renal failure undergoing chronic intermittent haemodialysis. The heparinoid administered as a single pre-dialysis i. v. injection of 34.4 anti-Xa units/kg body weight was compared to standard heparin (loading dose 2,500 IU + continuous infusion of 1,800 IU/hr). Mean anti-Xa plasma levels reached were 0.55 and 0.94 anti-Xa units/ml midway dialysis respectively. All 110 dialysis procedures were successfully performed without clotting or bleeding complications. Analysis of the number of clotted hollow-fibres within the dialysers showed a slight statistically calculated advantage in favour of heparin. Clinically no difference was detected. In conclusion, the heparinoid seems to be a good alternative means of anticoagulation in haemodialysis. As it is administered as a single i.v. pre-dialysis injection it will simplify the dialysis procedure.

Keywords

Chronic intermittent haemodialysis - LMW heparinoid

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References

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