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Thromb Haemost 1985; 54(02): 472-474
DOI: 10.1055/s-0038-1657876
DOI: 10.1055/s-0038-1657876
Original Article
The Effects of Nicotine on PGI2 Production by Rat Aortic Endothelium
Further Information
Publication History
Received 29 January 1985
Accepted 17 May 1985
Publication Date:
18 July 2018 (online)
Summary
The production of prostacyclin by rat aortic rings was measured following administration of nicotine by a single subcutaneous injection and after continuous subcutaneous infusion over 7 days. Single subcutaneous injections of nicotine at 1, 5, 10 or 20 mg/kg had no effect on prostacyclin production by rat aortic rings in comparison with controls. However, aortic rings obtained after 7 days continuous subcutaneous infusion of 0.54 g/ml of nicotine at the rate of 1 μl per hour produced significantly less prostacyclin than control animals.
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