Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause

L Balleisen; J Bailey; P-H Epping; H Schulte; J van de Loo

doi:10.1055/s-0038-1657877

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1985; 54(02): 475-479
DOI: 10.1055/s-0038-1657877

Original Article

Schattauer GmbH Stuttgart

Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause

L Balleisen

The Institute for Arteriosclerosis Research and Department of Internal Medicine, University of Münster, Münster, West Germany

,

J Bailey

The Institute for Arteriosclerosis Research and Department of Internal Medicine, University of Münster, Münster, West Germany

,

P-H Epping

The Institute for Arteriosclerosis Research and Department of Internal Medicine, University of Münster, Münster, West Germany

,

H Schulte

The Institute for Arteriosclerosis Research and Department of Internal Medicine, University of Münster, Münster, West Germany

,

J van de Loo

The Institute for Arteriosclerosis Research and Department of Internal Medicine, University of Münster, Münster, West Germany

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Abstract

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Summary

The Münster Arteriosclerosis Study (MAS) is a prospective, longitudinal epidemiological study on an industrial population in Westfalia aimed to establishing clinical and laboratory data with possible relationship to cardiovascular events. The data presented here describe the baseline measurements of fibrinogen, factor VIIc and factor VIIIc from the recruitment of 2880 male and 1306 female persons and their relationship to age, gender, body-weight, smoking, alcohol, pill-using and menopause. The correlations were made by means of a multiple regression analysis. We found an increase of those coagulation factors with age, a correlation of F VII and fibrinogen with body-weight index and of fibrinogen with cigarette smoking. No correlation was found for alcohol consumption. F VIII and F VII were significantly higher after onset of menopause and F VII and fibrinogen in women using the pill.

Keywords

Factor VII - Factor VIII - Fibrinogen - Epidemiology

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Referenzen

References
1 Dawber TR. The Framingham Study. The epidemiology of atherosclerotic disease. Harvard University Press; Cambridge, Massachussetts, and London: 1980
2 Meade TW, Chakrabarti R, Haines AP, North Y, Thompson SG, Brozovic M. Haemostatic function and cardiovascular death: early results of a prospective study. Lancet 1980; 1: 1050-1053
3 Assmann G, Oberwittler W, Schulte H, Schriewer H, Funke H, Epping PH, Hauss WH. Prädiktion und Früherkennung der koronaren Herzerkrankung. Prospektive epidemiologische Studie bei Betriebsangehörigen im Raum Westfalen. Internist 1980; 21: 446-459
4 Heller RF, Jabobs HS. Coronary heart disease in relation to age, sex and the menopause. Br Med J 1978; 1: 471-474
5 Inman WHW, Vessey MP, Westerholm B, Engelund A. Thromboembolic disorders and the steroidal content of oral contraceptives. A report to the committee on safety of drugs. Br Med J 1970; 2: 203-209
6 Kozararevic D, Vojvodic N, Dawber T, McGee D, Racic Z, Gordon T, Zuckel W. Frequency of alcohol consumption and morbidity and mortality. The Yugoslavia Cardiovascular Disease Study. Lancet 1980; 1: 613-616
7 Mann JI, Inman WHW, Thorogood M. Oral contraceptive use in older women and fatal myocardial infarction. Br Med J 1976; 2: 445-447
8 Petitti DB, Wingerd J, Pellegrin F, Ramachran S. Oral contraceptives, smoking, and other factors in relation to risk of venous thromboembolic disease. Am J Epidem 1978; 108: 480-485
9 Meade TW. Factor VII and ischaemic heart disease: epidemiological evidence. Haemostasis 1983; 13: 178-185
10 Sachs L. Angewandte Statistik. Springer Verlag, Berlin, Heidelberg; New York: 1978: 420
11 Brozovic M, Stirling Y, Harricks CH, North WRS, Meade TW. Factor VII in an industrial population. Br J Haematol 1974; 28: 381-391
12 Meade TW, North WRS, Chakrabarti R, Haines AP, Stirling Y. Population-based distributions of haemostatic variables. Br Med Bull 1977; 33: 283-288
13 Meade TW, Chakrabarti R, Haines AP, North WRS, Stirling Y. Characteristics affecting fibrinolysis activity and plasma fibrinogen concentrations. Br Med J 1979; 1: 153-156
14 Meade TW. Epidemiology of atheroma and thrombosis. In Bloom AL, Thomas DP. (Eds). Haemostasis and Thrombosis. Churchill and Livingstone, Edinburgh, London, Melbourne; New York: 1981: 575-592
15 Meade TW. Risk associations in the thrombotic disorders. In Prentice CRM, Saunders WB. (Eds.) Clinics in Haematology X: Thrombosis; 1981: 391-405
16 Meade TW. The epidemiology of atheroma and thrombosis. In van de Loo J, Prentice CRM, Beller FK. (Eds). The Thromboembolic Disorders. Schattauer Verlag; Stuttgart – New York: 1983: 107-125
17 Barrowcliffe TW, Kirkwood TBL. Standardization of factor VIII. 1. Calibration of British Standard for factor VIII clotting activity. Br J Haematol 1980; 46: 471-481
18 North WRS, Stirling Y, Meade TW. Common units for clotting factors assayed against different standards. Thromb Haemostas 1982; 48: 270-273
19 North WRS, Stirling Y, Meade TW. Variation between batches in clotting factor assays. Thromb Haemostas 1982; 48: 274-276