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Thromb Haemost 1985; 54(02): 539-543
DOI: 10.1055/s-0038-1657892
Original Article
Schattauer GmbH Stuttgart

Plasma Concentrations of Platelet-Specific Proteins in Different Stages of Essential Hypertension: Interactions between Platelet Aggregation, Blood Lipids and Age

J Yamanishi
The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
,
H Sano
The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
,
K Saito
The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
,
Y Furuta
The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
,
H Fukuzaki
The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
› Author Affiliations
Further Information

Publication History

Received 19 March 1985

Accepted 25 June 1985

Publication Date:
18 July 2018 (online)

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Summary

Plasma β-thromboglobulin (βTG) and platelet factor 4 (PF4) were significantly higher in a group of 116 hypertensive men than in a normotensive group of 142 men. They increased with the stage of hypertension but the level did not correlate with the age of the subjects. Platelet aggregation was similar in the two groups and positively correlated with the age of the subjects in the normotensive group but not in the hypertensive group. A strong positive correlation was observed between the levels of plasma βTG and PF4 and between platelet aggregation to ADP and that to epinephrine in both the hypertensive and normotensive groups. However, there was no correlation between the level of plasma βTG or PF4 and platelet aggregation. Plasma antithrombin III was lower in the hypertensive group than in the normotensive group.

These studies suggest that plasma levels of PTG and PF4 are closely related to the stage of hypertension and are better indicators than aggregation of in vivo platelet activation in hypertensive subjects. Enhanced platelet activation may be involved in the acceleration of hypertensive arteriovascular damage and atherosclerosis.

Keywords

Platelet aggregation - Hypertension - Age - β-thromboglobulin - Platelet factor 4
 

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