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Thromb Haemost 1985; 54(03): 595-598
DOI: 10.1055/s-0038-1660077
Original Article
Schattauer GmbH Stuttgart

Intrahepatic Kinetics of lndium-111-Labelled Platelets

A M Peters
*   The Department of Diagnostic Radiology, Royal Postgraduate Medical School, London, UK
,
S H Saverymuttu
**   The Department of Medicine, Royal Postgraduate Medical School, London, UK
,
F Malik
*   The Department of Diagnostic Radiology, Royal Postgraduate Medical School, London, UK
,
P W Ind
**   The Department of Medicine, Royal Postgraduate Medical School, London, UK
,
J P Lavender
*   The Department of Diagnostic Radiology, Royal Postgraduate Medical School, London, UK
› Author Affiliations
Further Information

Publication History

Received 26 October 1984

Accepted after resubmission 17 May 1985

Publication Date:
19 July 2018 (online)

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Summary

The intrahepatic kinetics of 111indium-labelled platelets have been studied using dynamic gamma camera scintigraphy immediately following injection. Platelets labelled in saline with mIn-oxine or 111In-acetylacetonate underwent rapidly reversible hepatic sequestration, indicating that they were “activated”. Platelets labelled in plasma with 111In-tropolonate, however, did not display this phenomenon. On the assumption that plasma-labelled platelets display a normal initial bio-distribution, mean intrahepatic platelet transit time, as a factor of the transit time of 99m-Tc labelled red cells, was 1.45 ± SE 0.12 (n = 6), implying the normal presence of a small intrahepatic platelet pool. Unlike the liver, transit through the spleen was not sensitive to the labelling medium; thus the mean intrasplenic transit time of plasma-labelled platelets was 9.3 ± SE 0.7 min (n = 10), and of saline-labelled platelets 9.5 ± SE 0.3 min (n = 8).

Keywords

IIIIn-platelets - Platelets kinetics - Liver
 

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