Lipoproteine und Thrombozyten

E. Malle; G. M. Kostner; W. Sattler

doi:10.1055/s-0038-1660306

Hämostaseologie, Inhaltsverzeichnis

Hamostaseologie 1992; 12(01): 001-006
DOI: 10.1055/s-0038-1660306

Übersichtsarbeit/Review Articles

Schattauer GmbH

Lipoproteine und Thrombozyten

E. Malle

¹Philipps-Universität, Zentrum Innere Medizin, Abteilung Endokrinologie und Stoffwechsel, Marburg/Lahn, Bundesrepublik Deutschland (Leiter: Prof. Dr. H. Kaffarnik)

,

G. M. Kostner

²Karl-Franzens-Universität, Institut für Medizinische Biochemie, Graz, Österreich (Direktor: Prof. Dr. G. M. Kostner)

,

W. Sattler

³Heart Research Institute, Dept. Medical Biochemistry, Sydney, Australien

› Institutsangaben

Abstract

Zusammenfassung

Die Entstehung von Atherosklerose findet unter anderem ihren Ursprung in Läsionen des Endothels, die in Wechselwirkung mit aktivierten Thrombozyten, glatten Muskelzellen, Makrophagen, Wachstumsfaktoren, Lipoproteinen und Cholesterin zur Bildung atherosklerotischer Plaques führen können. Hohe Plasmakonzentrationen an Cholesterin, atherogenen Lipoproteinen, oxidativ modifizierten atherogenen Lipoproteinen sowie verminderte Plasmakonzentrationen an Antioxidanzien bedingen erhöhte Sensitivität und Reaktivität von Thrombozyten sowie gleichzeitig ein erhöhtes Risiko atherosklerotischer und kardiovaskulärer Veränderungen bei hyperlipämischen Patienten.

Schlüsselwörter

Thrombozytenaggregation - Lipoproteine - modifizierte Lipoproteine

Key words

Platelet aggregation - lipoproteins - modified lipoproteins

Volltext

Referenzen

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