The Inability of Propranolol and Aspirin to Inhibit the Response of Fibrinolytic Activity and Factor VIII-Antigen to Infusion of DDAVP

E J P Brommer; F H M Derkx; M M Barrett-Bergshoeff; M A D H Schalekamp

doi:10.1055/s-0038-1661015

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1984; 51(01): 042-044
DOI: 10.1055/s-0038-1661015

Original Article

Schattauer GmbH Stuttgart

The Inability of Propranolol and Aspirin to Inhibit the Response of Fibrinolytic Activity and Factor VIII-Antigen to Infusion of DDAVP

E J P Brommer

^*The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands

,

F H M Derkx

^**The Department of Internal Medicine, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands

,

M M Barrett-Bergshoeff

^*The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands

,

M A D H Schalekamp

^**The Department of Internal Medicine, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands

› Author Affiliations

Abstract

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Summary

We tested the response of the fibrinolytic activity and factor VIII-antigen levels to infusion of DDAVP in healthy volunteers and we studied the influence of propranolol and aspirin on this response. After DDAVP, 0.4 μg/kg in 10 min i. v., the fibrinolytic activity of redissolved euglobulins rose from 179 to 452 mm² (lysis area of fibrin plates); after pretreatment with propranolol, 320 mg per day during 7 days, DDAVP induced a similar rise (from 166 to 471 mm²) and after pretreatment with a single dose of aspirin, 600 mg, ingested 5 hr before the DDAVP infusion, the lysis area increased from 159 to 455 mm²

Factor VIII-antigen level increased within 60 min after DDAVP from 104 to 208%; after pretreatment with propranolol from 111 to 230% and after a single dose of aspirin, DDAVP induced a rise from 107 to 206%.

From these data we conclude that neither baseline levels nor the release of plasminogen activator or factor VIII after DDAVP infusion are influenced by β-blockade or by interference with prostaglandin synthesis.

Key Words

Aspirin - DDAVP - Fibrinolytic activity - Plasminogen activator (t-PA) - Propranolol - Prostaglandin synthesis

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References

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