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Thromb Haemost 1984; 51(01): 045-049
DOI: 10.1055/s-0038-1661016
Original Article
Schattauer GmbH Stuttgart

Drugs Effect on Platelet Survival Time: Comparison of Two Pyrimido-Pyrimidine Derivatives in Patients with Aortic or Mitral Replacement

J Schbath
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
J P Boissel
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
B Mathy
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
D Ville
2   The Laboratoire de Médicine Nucléaire, Pr. Viala, Hôpital E. Herriot, Lyon, France
,
E Benveniste
3   The Laboratoire d’Hématologie, Pr. Germain, Hôpital Cardiologique, Lyon, France
,
B Sanchini
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
A Leizorovicz
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
J Belleville
3   The Laboratoire d’Hématologie, Pr. Germain, Hôpital Cardiologique, Lyon, France
,
M Dechavanne
2   The Laboratoire de Médicine Nucléaire, Pr. Viala, Hôpital E. Herriot, Lyon, France
,
P Maitre
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
J Gillet
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
,
A Bentamar
1   The Unité de Pharmacologie Clinique, Hôpital Cardiologique, Lyon, France
› Author Affiliations
Further Information

Publication History

Received 12 August 1983

Accepted 10 November 1983

Publication Date:
19 July 2018 (online)

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Summary

A prospective randomized trial of the effects of 2 antiplatelet aggregating drugs, dipyridamole (375 mg/d), a related substance RA 233 (1500 mg/d) and placebo, concomitantly with oral anticoagulants, was carried out in patients with prior valvular replacement. The study was aimed to determine effect on platelet survival time (PST) of these 2 agents. The trial sample consisted of 40 males and 15 females aged 40–70 years (average 53 years). 32 received Björk-Shiley valve in aortic position; 23 underwent mitral valve replacement: 3 with Cooley-Cutter, 11 with Lillehei- Kaster 500 and 9 with Starr-Edwards 6120 prostheses; 28 patients had aortic stenosis, 21 aortic insufficiency. All the PST measured after 3 months of treatment were within normal ranges and not different between placebo, dipyridamole or RA 233 treated subjects: averages in days were, respectively, 7.49, 7.11 and 6.88. The present study did not support the claim that modem valve prosthesis could lead to a shortened PST.

Key Words

Platelet - Survival time - Clinical trial - Heart valve - Antiplatelet agents - Placebo
 

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