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Thromb Haemost 1984; 51(01): 057-060
DOI: 10.1055/s-0038-1661019
Original Article
Schattauer GmbH Stuttgart

A Study of the Possible Role of Mesothelium as a Surface for Flowing Blood

J M F Clarke
The Departments of Surgical Studies, Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.
,
R M Pittilo
The Departments of Surgical Studies, Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.
,
S J Machin
The Departments of Surgical Studies, Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.
,
N Woolf
The Departments of Surgical Studies, Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.
› Author Affiliations
Further Information

Publication History

Received 11 March 1983

Accepted 16 November 1983

Publication Date:
19 July 2018 (online)

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Summary

Mouse mesothelium has been examined as a surface for supporting blood flow. We have examined ten pieces of intact mesothelium and ten pieces of damaged mesothelium following 10 min exposure to flowing blood in a Baumgartner chamber. Scanning electron microscopy of the intact specimens demonstrated no adhering blood platelets, whereas the damaged specimens were found to be covered with large numbers of adhering platelets. In addition we have demonstrated that undamaged mesothelium does not appear to be morphologically altered after exposure to blood, and that undamaged mesothelium produces significantly more prostacyclin than damaged control. These findings suggest that mesothelial cells hold promise as a lining for prosthetic vascular implants.

Key Words

Mesothelium - Prostacyclin - Scanning electron microscopy - Platelets - Artificial circulation - Vascular prosthesis
 

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