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Thromb Haemost 1984; 51(01): 108-109
DOI: 10.1055/s-0038-1661033
Original Article
Schattauer GmbH Stuttgart

Dysfibrinogenemia (Fibrinogen Dusard) Associated with Impaired Fibrin-Enhanced Plasminogen Activation

H R Lijnen
The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium
,
J Soria
*   The Unité de Recherches de Thrombose Expérimentale, INSERM U.150, LA 334, CNRS, Hôpital Lariboisière, Paris, France
,
C Soria
*   The Unité de Recherches de Thrombose Expérimentale, INSERM U.150, LA 334, CNRS, Hôpital Lariboisière, Paris, France
,
D Collen
The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium
,
J P Caen
*   The Unité de Recherches de Thrombose Expérimentale, INSERM U.150, LA 334, CNRS, Hôpital Lariboisière, Paris, France
› Author Affiliations
Further Information

Publication History

Received 31 May 1983

Accepted 09 December 1983

Publication Date:
19 July 2018 (online)

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Summary

The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most likely related to the history of recurrent thrombosis and pulmonary embolism observed in this family.

Key Words

Dysfibrinogenemia - Impaired fibrinolysis - Fibrinogen Dusard
 

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