Dysfibrinogenemia (Fibrinogen Dusard) Associated with Impaired Fibrin-Enhanced Plasminogen Activation

H R Lijnen; J Soria; C Soria; D Collen; J P Caen

doi:10.1055/s-0038-1661033

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1984; 51(01): 108-109
DOI: 10.1055/s-0038-1661033

Original Article

Schattauer GmbH Stuttgart

Dysfibrinogenemia (Fibrinogen Dusard) Associated with Impaired Fibrin-Enhanced Plasminogen Activation

H R Lijnen

The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium

,

J Soria

^*The Unité de Recherches de Thrombose Expérimentale, INSERM U.150, LA 334, CNRS, Hôpital Lariboisière, Paris, France

,

C Soria

^*The Unité de Recherches de Thrombose Expérimentale, INSERM U.150, LA 334, CNRS, Hôpital Lariboisière, Paris, France

,

D Collen

The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium

,

J P Caen

^*The Unité de Recherches de Thrombose Expérimentale, INSERM U.150, LA 334, CNRS, Hôpital Lariboisière, Paris, France

› Author Affiliations

Abstract

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Summary

The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most likely related to the history of recurrent thrombosis and pulmonary embolism observed in this family.

Key Words

Dysfibrinogenemia - Impaired fibrinolysis - Fibrinogen Dusard

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References

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