Influence of Vitamin E on Plasma Malondialdehyde- Like Material in Man

Summary

The behaviour of plasma malondialdehyde-like material (MDA-LM) was evaluated in 13 healthy subjects by a single-blind study that consisted of placebo (30 days), vitamin E treatment (300 mg/day) (30 days) and placebo (30 days). The study demonstrated that MDA-LM did not change during placebo treatment while it significantly decreased after vitamin E administration.

Keywords

Malondialdehyde-like material - Vitamin E

• References

• 1 Metz SA. Anti-inflammatory agents as inhibitors of prostaglandin synthesis in man. Med Clin North Am 1981; 65: 713-757
• 2 Frank L, Massaro D. Oxygen toxicity. Am J Med 1980; 69: 117-124
• 3 Privett OS, Cortesi R. Observations on the role of vitamin E in the toxicity of oxidized rat. Lipids 1972; 7: 780-788
• 4 Trostler N, Brady PS, Ranson DR, Leveille GA. Influence of dietary vitamin E of malondialdehyde levels in liver and adipose tissue and on glutathione peroxidase and reductase activities in liver and erythrocytes of lean and obese mice. J Nutr 1979; 109: 354-362
• 5 Hafeman DG, Hoekstra WG. Lipid peroxidation in vivo during vitamin E and selenium deficiency in the rat as monitored by ethane evolution. J Nutr 1977; 107: 666-672
• 6 Huijgens PC, van den Berg CA M, Imandt LM F M, Langenhuijsen MM A C. Vitamin E and platelet aggregation. Acta Haematol 1981; 65: 217-218
• 7 Steiner M, Anastasi J. Vitamin E, an inhibitor of the platelet release reaction. J Clin Invest 1976; 57: 732-737
• 8 Musca A, Cordova C, Violi F, Perrone A, Alessandri C, Salvadori F. Vitamin E, plasma lipids and platelet function. Abstract 3rd European Symposium on Metabolism Padua, Italy: 28.05.1981
• 9 Lake AM, Stuart MJ, Oski FA. Vitamin E deficiency and enhanced platelet function: reversal following E supplementation. J Pediatr 1977; 90: 722-725
• 10 Steiner H. Effect of alpha-tocopherol administration on platelet function in man. Thromb Haemostas 1983; 49: 73-77
• 11 Santos MT, Walles J, Agnor J, Vilches J. Determination of plasma malondialdehyde-like material and its clinical application in stroke patients. J Clin Pathol 1980; 33: 973-976
• 12 Smith JB, Ingerman CM, Silver MJ. Malondialdehyde formation as an indicator of prostaglandin production by human platelets. J Lab Clin Med 1976; 88: 167-172
• 13 Okuma M, Steiner M, Baldini M. Studies on lipid peroxides in platelets. I. Method of assay and effect of storage. J Lab Clin Med 1970; 75: 283-296
• 14 Dousset JC, Trouilh M, Foglietti MJ. Plasma malondialdehyde levels during myocardial infarction. Clin Chim Acta 1983; 129: 319-322
• 15 Pryor WA, Stanley JP, Blair E. Autoxidation of polyunsatured fatty acids II A suggested mechanism for the formation of TBA-reactive materials from prostaglandin-like endoperoxides. Lipids 1976; 11: 370-379
• 16 Macfarlane DE, Gardner S, Lipson C, Mills DC B. Malondialdehyde production by platelets during secondary aggregation. Thromb Haemostas 1977; 38: 1002-1009
• 17 Bieri JG, Corash L, Hubbard VS. The medical use of vitamin E. N Eng J Med 1983; 308: 1063-1071
• 18 Toppel AL. Lipid peroxidation damage to cell components. Fed Proc 1973; 32: 1870-1874
• 19 Solonen JT, Alfthan G, Huttunen JK, Pikkarainen J, Puska P. Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. Lancet 1982; 2: 175-179
• 20 Haeger K. Walking distance and arterial flow during long-term treatment of intermittent claudication with alpha-tocopherol. Vasa 1973; 2: 280-287
• 21 Vatassery GT, Krezowski AM, Eckfeldt JH. Plasma vitamin E concentration in human blood plasma and platelets. Am J Clin Nutr 1983; 37: 1020-1024
• 22 Steiner M. Inhibition of platelet aggregation by alpha-tocopherol. In: de Duve C, Hayaishi O. (eds.) Tocopherol, oxigen and biomembranes. pp 143-163 Amsterdam: Elsevier/North Holland: 1978