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Thromb Haemost 1984; 52(01): 050-052
DOI: 10.1055/s-0038-1661135
Original Article
Schattauer GmbH Stuttgart

Inhibitor to Factor VIII in Mild Haemophilia

P J Kesteven
The Coagulation Laboratory, Department of Haematology, St. Thomas’ Hospital, London, England
,
L J Holland
The Coagulation Laboratory, Department of Haematology, St. Thomas’ Hospital, London, England
,
A S Lawrie
The Coagulation Laboratory, Department of Haematology, St. Thomas’ Hospital, London, England
,
G F Savidge
The Coagulation Laboratory, Department of Haematology, St. Thomas’ Hospital, London, England
› Author Affiliations
Further Information

Publication History

Received 05 August 1983

Accepted 14 May 1984

Publication Date:
19 July 2018 (online)

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Summary

Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for symptomatic management. When inhibitor titres were low, endogenous F VIII stimulation, by DDAVP, was less immunogenic than the administration of exogenous F VIII concentrates. This inhibitor displayed characteristics of an autoantibody, and was characterised as an immunoglobulin of IgG subtype.

Keywords

F VIII inhibitors - Activated prothrombin complex concentrates - Porcine F VIII - DDAVP
 

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