Venous Thrombosis Following Diagnostic Transvenous Catheterization by Percutaneous Catheter Insertion: An Evaluation of Desmopressin as a Thromboprophylactic Agent

D W T Nilsen; J Haerem; A Westheim; A Skjennald; H Grendahl; H C Godal

doi:10.1055/s-0038-1661153

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1984; 52(02): 121-123
DOI: 10.1055/s-0038-1661153

Original Article

Schattauer GmbH Stuttgart

Venous Thrombosis Following Diagnostic Transvenous Catheterization by Percutaneous Catheter Insertion: An Evaluation of Desmopressin as a Thromboprophylactic Agent

Authors

D W T Nilsen

The Haematological Research Laboratory, Ullevål Hospital, Oslo, Norway
J Haerem

¹The Department of Cardiology, Ullevål Hospital, Oslo, Norway
A Westheim

²The Laboratory of Clinical Physiology, Ullevål Hospital, Oslo, Norway
A Skjennald

³The Department of Radiology, Ullevål Hospital, Oslo, Norway
H Grendahl

¹The Department of Cardiology, Ullevål Hospital, Oslo, Norway
H C Godal

The Haematological Research Laboratory, Ullevål Hospital, Oslo, Norway

Abstract

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Summary

The preventive effect of desmopressin with respect to catheter induced thrombosis was studied in a randomized double-blind trial, consisting of 30 patients undergoing percutaneous transcubital right heart catheterization. Phlebography of the catheterized arm was performed after five days. The frequency of postcatheterization thrombosis was reduced by 33 per cent, from 86 per cent in the treatment group to 53 per cent in the control group (0.1 <p <0.2). This effect was restricted to minor thrombi, whereas major thrombosis could not be prevented.

Patient materials such as that of the present study, may become useful in preliminary investigations of thromboprophylactic agents.

Keywords

Transvenous catheterization - Desmopressin - Fibrinolysis - Venous thrombosis

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Referenzen

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