Summary
The novel fast inhibitor to tissue plasminogen activator in plasma has been determined
in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women
with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis
or previous history of thrombosis, diabetes and others). In healthy fertile non-pregnant
women, the inhibitor concentration was found to be 0.4 ± 0.7 U/ml. In pregnant women
the concentration stayed at this level until week 10, but then an almost linear increase
was found, reaching about 6.5 U/ml at week 40. In plasma samples from the patients
with risk pregnancies many with deviating concentrations were found. Thus, in the
last trimester a range of 0-24.0 U/ml was found in these patients, as compared to
4.0-6.4 U/ml in healthy pregnant women. The pathophysiological impact of this finding
is at present unclear.
Keywords
Fibrinolysis - Plasminogen activator inhibition - Pregnancy - Risk pregnancy
