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Thromb Haemost 1984; 52(02): 138-143
DOI: 10.1055/s-0038-1661158
Original Article
Schattauer GmbH Stuttgart

Fifteen Coagulation and Fibrinolysis Parameters in Diabetes Mellitus and in Patients with Vasculopathy

M Christe
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
J Fritschi
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
B Lämmle
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
T H Tran
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
G A Marbet
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
W Berger
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
F Duckert
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
› Institutsangaben
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Publikationsverlauf

Received 04. April 1984

Accepted 02. Juni 1984

Publikationsdatum:
19. Juli 2018 (online)

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Summary

Fifteen haemostasis parameters have been measured in 48 normal persons, 36 diabetics without and 44 with complications and 27 with peripheral arterial disease. Since the patients groups are older than normals, part of the differences are due to age. However, the differences are significant between normals and patients. They become highly significant for the diabetics with complications and nephropathy (Table 7). In diabetics without complications factor VIII functions, fibrinogen and thrombin time are related to age whereas there is a negative correlation for the fibrinolytic activity and antithrombin III. The diabetic complications shade off the correlations, which subsist only for VIIIR: CoF, VIIIR: Ag, ATIII and lysis before stasis. With Hbalc as dependent variable VIIIR:CoF is the only significant predictor variable in diabetics (Table 9).

Keywords

Diabetes mellitus - Coagulation - Fibrinolysis - Nephropathy - Vasculopathy
 

  • References

  • 1 Jones RL, Peterson CM. The fluid phase of coagulation and the accelerated atherosclerosis of diabetes mellitus. Diabetes 1981; 30 (Suppl) (Suppl. 01) 33-38
    CrossrefPubMedSuche in Google Scholar
  • 2 Christe M, Gattlen P, Fritschi J, Lämmle B, Berger W, Marbet GA, Duckert F. The contact phase of blood coagulation in diabetes mellitus and in patients with vasculopathy. Thromb Haemostas. 1984 (in press)
    PubMedSuche in Google Scholar
  • 3 Fritschi J, Christe M, Lämmle B, Berger W, Marbet GA, Duckert F. Platelet aggregation, β-thromboglobulin and platelet factor 4 in diabetes mellitus and in patients with vasculopathy. Thromb Haemostas. 1984 (in press)
    PubMedSuche in Google Scholar
  • 4 Borkenstein MH, Muntean WE. Elevated factor VIII activity and factor VUI-related antigen in diabetic children without vascular disease. Diabetes 1982; 31: 1006-1009
    CrossrefPubMedSuche in Google Scholar
  • 5 Gensini GF, Abbate R, Favilla S, Neri Serneri GG. Changes of platelet function and blood clotting in diabetes mellitus. Thromb Haemostas 1979; 42: 983-993
    PubMedSuche in Google Scholar
  • 6 Kazmier FJ, Bowie EJ W, O’Fallon WM, Zimmerman BR, Osmundson PJ, Palumbo PJ. A prospective study of peripheral occlusive arterial disease in diabetes. IV Platelet and plasma functions. Mayo Clin Proc 1981; 56: 243-253
    PubMedSuche in Google Scholar
  • 7 Bern MM, Cassani MP, Horton J, Rand L, Davis G. Changes in fibrinolysis and factor VIII coagulant, antigen, and ristocetin cofactor in diabetes mellitus and atherosclerosis. Thromb Res 1980; 19: 831-839
    CrossrefPubMedSuche in Google Scholar
  • 8 Aimér LO, Sundkvist G, Lilja B. Fibrinolytic activity, autonomic neuropathy, and circulation in diabetes mellitus. Diabetes 1983; 32 (Suppl) (Suppl. 02) 4-7
    CrossrefPubMedSuche in Google Scholar
  • 9 Gunnarsson R, Nyman D, Walinder O, Oestman J. Fibrinolytic activity and diabetes control. Evidence for a relationship Acta Med Scand 1980; Suppl (Suppl. 639) 23-24
    PubMedSuche in Google Scholar
  • 10 Ewing DJ, Clarke BF. Diagnosis and Management of diabetic autonomic neuropathy. Br med J 1982; 285: 916-918
    CrossrefPubMedSuche in Google Scholar
  • 11 Dettli L. Elimination kinetics and dosage adjustment of drugs in patients with kidney disease. Prog Pharmacol. Gustav Fischer Verlag; Stuttgart: 1977. 1 1-34
    Suche in Google Scholar
  • 12 Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 1957; 17: 237-246
    CrossrefPubMedSuche in Google Scholar
  • 13 Koller F, Loeliger A, Duckert F. Experiments on a new clotting factor (Factor VII). Acta Haematol 1951; 6: 1-18
    CrossrefPubMedSuche in Google Scholar
  • 14 Tran TH, Duckert F. Preparation of factor VUI-free plasma by immunoaffinity chromatography on insolubilized antibodies against factor VIII related antigen. Haemostasis 1983; 13: 73-77
    PubMedSuche in Google Scholar
  • 15 Tran TH, Duckert F. Dissociation of factor VIII procoagulant antigen VIII: CAg and factor VIII related antigen VIIIR: Ag by EDTA. Influence of divalent cation on the binding of VIII: CAg and VIIIR: Ag. Thromb Haemostas 1983; 50: 547-551
    PubMedSuche in Google Scholar
  • 16 Tran TH, Marbet GA, Duckert F. Rabbit antibodies against the procoagulant activity (VIII :C) of human factor VIII. Thromb Haemostas 1981; 46: 699-705
    PubMedSuche in Google Scholar
  • 17 Nie NH, Hull CH, Jenkins JG, Steinbrenner K, Bent DH. Statistical package for the social sciences. 2. edition McGraw Hill, Book Company; New York: 1975
    Suche in Google Scholar
  • 18 Tsianos EB, Stathakis NE. Soluble fibrin complexes and fibrinogen heterogeneity in diabetes mellitus. Thromb Haemostas 1980; 44: 130-134
    PubMedSuche in Google Scholar
  • 19 Banerjee RN, Sahni AL, Kumar V. Fibrinocoagulopathy in maturity onset diabetes mellitus and atherosclerosis. Thrombos Diathes Haemorrh 1973; 30: 123-132
    PubMedSuche in Google Scholar
  • 20 Fuller JH, Keen H, Jarrett RJ, Omer T, Meade TW, Chakrabarti R, North WR S, Stirling Y. Haemostatic variables associated with diabetes and its complications. Br Med J 1979; 2: 964-966
    CrossrefPubMedSuche in Google Scholar
  • 21 Cederholm-Williams SA, Doman TL, Turner RC. The metabolism of fibrinogen and plasminogen related to diabetic retinopathy in man. Eur J clin Invest 1981; 11: 133-138
    CrossrefPubMedSuche in Google Scholar
  • 22 Masperi R, Mussoni L, Bini A, Donati MB, Chiumello G. Haemostatic variables in uncomplicated diabetic children. Thromb Haemostas 1980; 43: 227
    PubMedSuche in Google Scholar
  • 23 Fuller H. Haemostatic function tests associated with diabetic microangiopathy. Horm Metab Res 1981; 11 (Suppl) 59-62
    Thieme ConnectPubMedSuche in Google Scholar
  • 24 Vergani C, Bettale G, Mari D, Mannucci PM. Relationships between metabolic and hemostatic variables in uncomplicated diabetes. Acta Diabet Lat 1981; 18: 199-206
    CrossrefPubMedSuche in Google Scholar
  • 25 Doman TL, Rhymes IL, Cederholm-Williams SA, Rizza CR, Pepys MB, Bron AJ, Turner RC. Plasma haemostatic factors and diabetic retinopathy. Eur J clin Invest 1983; 13: 231-235
    CrossrefPubMedSuche in Google Scholar
  • 26 Lufkin EG, Fass DN, O’Fallon WM, Bowie EJ W. Increased von Willebrand factor in diabetes mellitus. Metabolism 1979; 28: 63-66
    CrossrefPubMedSuche in Google Scholar
  • 27 Giustolisi R, Lombardo T, Musso R, Cacciola E. Factor VIII antigen plasma levels in diabetes mellitus. Enhanced endothelial release and storage. Thromb Haemostas 1980; 44: 46
    PubMedSuche in Google Scholar
  • 28 Coller BS, Frank RN, Milton RC, Gralnick HR. Plasma cofactors of platelet function: Correlation with diabetic retinopathy and hemoglobin A1a-c . Ann Intern Med 1978; 88: 311-316
    CrossrefPubMedSuche in Google Scholar
  • 29 Hughes A, McVerry BA, Wilkinson L, Goldstone AH, Lewis D, Bloom A. Diabetes, a hypercoagulable state? Haemostatic variables in newly diagnosed type 2 diabetic patients. Acta Haematol 1983; 69: 254-259
    CrossrefPubMedSuche in Google Scholar
  • 30 Brooks AM V, Hussein S, Chesterman CN, Martin JF, Alford FP, Pennington DG. Platelets, coagulation and fibrinolysis in patients with diabetic retinopathy. Thromb Haemostas 1983; 49: 123-127
    PubMedSuche in Google Scholar
  • 31 Bunn HF. Non-enzymatic glycosylation of protein, relevance to diabetes. Am J Med 1981; 70: 325-330
    CrossrefPubMedSuche in Google Scholar
  • 32 Ceriello A, Dello Russo P, Zuccotti C, Florio A, Nazzaro S, Pietrantuono C, Rosato GB. Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation. A preliminary report. Thromb Haemostas 1983; 50: 633-634
    PubMedSuche in Google Scholar
  • 33 Grignani G, Gamba G, Geroldi D, Pacchiarini L, Solerte B, Ferrari E, Ascari E. Enhanced antithrombotic mechanisms in patients with maturity onset diabetes mellitus without thromboembolic complications. Thromb Haemostas 1981; 46: 648-651
    PubMedSuche in Google Scholar
  • 34 Sowers JR, Tuck ML, Sowers DK. Plasma antithrombin III and thrombin generation time: correlation with hemoglobin A, and fasting serum glucose in young diabetic women. Diabetes Care 1980; 3: 655-658
    CrossrefPubMedSuche in Google Scholar
  • 35 Juhan-Vague I, Vague P, Poisson C, Aillaud MF, Mendez C, Collen D. Effect of 24 hours of normoglycaemia on tissue-type plasminogen activator plasma levels in insulin-dependent diabetes. Thromb Haemostas 1984; 51: 97-98
    PubMedSuche in Google Scholar