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Thromb Haemost 1984; 52(02): 157-159
DOI: 10.1055/s-0038-1661162
Original Article
Schattauer GmbH Stuttgart

Clearance and In Vivo Release by Heparin of Human Platelet Factor 4 (PF4) in the Rabbit

M Prosdocimi
The Fidia Research Laboratories, Dept, of Cytopharmacology, Abano Terme, Italy
,
N Scattolo
*   The Istituto Semeiotica Medica, 2nd Chair of Medicine, University of Padova Medical School, Padova, Italy
,
A Zatta
The Fidia Research Laboratories, Dept, of Cytopharmacology, Abano Terme, Italy
,
F Fabris
*   The Istituto Semeiotica Medica, 2nd Chair of Medicine, University of Padova Medical School, Padova, Italy
,
F Stevanato
*   The Istituto Semeiotica Medica, 2nd Chair of Medicine, University of Padova Medical School, Padova, Italy
,
A Girolami
*   The Istituto Semeiotica Medica, 2nd Chair of Medicine, University of Padova Medical School, Padova, Italy
,
G Cella
*   The Istituto Semeiotica Medica, 2nd Chair of Medicine, University of Padova Medical School, Padova, Italy
› Author Affiliations
Further Information

Publication History

Received 22 June 1984

Accepted 03 July 1984

Publication Date:
19 July 2018 (online)

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Summary

13 male New Zealand rabbits were injected with two different doses (25 μg/Kg and 100 μg/Kg) of human platelet factor 4 antigen (PF4). The disappearance of the protein was extremely fast with an half-life for the fast component of 1.07 ± 0.16 and 1.76 ± 0.11 min respectively. The half-life for the slow component, detectable only with the highest dosage, was 18.8 min.

The administration of 2500 I.U. of heparin 30 min after PF4 administration induced a partial release of the injected protein and its clearance from plasma was slow, with half-life of 23.3 ± 5.9 min and 30.9 ± 2.19 min respectively.

Keywords

Human platelet factor 4 - Heparin - Rabbit
 

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