Platelet Survival in Patients with Angiographically Diseased and Normal Coronary Arteries

Summary

Platelets may contribute to the pathogenesis of atherosclerosis and to the complications of coronary artery disease. Therefore, platelet kinetics were studied in 69 patients with angiographically documented coronary artery disease and in 16 patients with a normal coronary angiogram. Platelet survival time was calculated from the decay of radioactivity after injection of ⁵¹Cr-labeled autologous platelets. None of the mathematical models used was able to discriminate between the two patients groups. No correlation existed between survival time and extent of the arterial disease. Patients with a high serum cholesterol did not exhibit an enhanced platelet consumption. Thus, these studies do not support the idea that platelet turnover is enhanced in patients with coronary artery disease as compared to those with normal coronary arteries.

Keywords

Blood platelets - Coronary disease - Angina pectoris - Arteriosclerosis

• References

• 1 French JE. Atherogenesis and thrombosis. Semin Hematol 1971; 8: 84-94
• 3 Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med 1976; 295: 369-377
• 4 Steele P, Battock D, Pappas G, Genton E. Correlation of platelet survival time with occlusion of saphenous vein aorto-coronary bypass grafts. Circulation 1976; 53: 685-687
• 5 Ritchie JL, Harker LA. Platelet and fibrinogen survival in coronary atherosclerosis. Response to medical and surgical therapy Am J Cardiol 1977; 39: 595-598
• 6 Steele P, Rainwater J. Effects of dietary and pharmacological alteration of serum lipids on platelet survival time. Circulation 1978; 58: 365-367
• 7 Fuster V, Chesebro JH, Frye RL, Elveback LR. Platelet survival and the development of coronary artery disease in the young adult: Effects of cigarette smoking, strong family history and medical therapy. Circulation 1981; 63: 546-551
• 8 Jonkers JJ C, den Ottolander GJ H. Platelet function studies in normal volunteers and patients with angina pectoris. Thromb Haemostas 1979; 42: 144 (Abstr.)
• 9 Najean Y, Dassin E, Renner C, Wacquet M. Cinétique plaquettaire au cours des maladies artérielles. Nouv Presse Méd 1979; 8: 3813-3816
• 10 Doyle DJ, Chesterman CN, Cade JF, McGready JR, Rennie GC, Morgan FJ. Plasma concentrations of platelet-specific proteins correlated with platelet survival. Blood 1980; 55: 82-84
• 11 de BoerA, Ping HanM, Turpie AG, Butt R, Gent M, Genton E. Platelet tests and antiplatelet drugs in coronary artery disease. Circulation 1983; 67: 500-504
• 12 Meuleman DG, Vogel GM T, Stulemeijer SM, Moelker HC. Analysis of platelet survival curves in an arterial thrombosis model in rats. Thromb Res 1980; 20: 31-43
• 13 Mustard JF. Platelet survival. Thromb Haemostas 1978; 40: 154-162
• 14 Harker LA, Slichter SJ, Scott CR. Homocystinemia: vascular injury and arterial thrombosis. N Engl J Med 1974; 291: 537-543
• 15 Uhlemann RE, Tenpas JH, Lucky AW, Shulman JD, Mudd SH, Shulman NR. Platelet survival and morphology in homocystinuria due to cystathionine synthetase deficiency. N Engl J Med 1976; 295: 1283-1286
• 16 Hill-Zobel RL, Pyeritz RE, Scheffel U, Malpica O, Engin S, Camargo E, Abbott M, Guilarte TR, Hill J, McIntyre PA, Murphy EA, Tsan MF. Kinetics and distribution of “Indium-labeled platelets” in patients with homocystinuria. N Engl J Med 1982; 307: 781-786
• 17 Steele P, Rainwater J, Vogel R, Genton E. Platelet suppressant therapy in patients with coronary artery disease. JAMA 1978; 240: 228-231