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Thromb Haemost 1984; 52(02): 167-171
DOI: 10.1055/s-0038-1661165
Original Article
Schattauer GmbH Stuttgart

Platelet Production in Myocardial Infarction and Sudden Cardiac Death

E A Trowbridge
The University of Sheffield, Department of Medical Physics and Clinical Engineering, Sheffield, England
,
D N Slater
1   The Department of Pathology, the Royal Hallamshire Hospital, Sheffield, England
,
Y T Kishk
2   The Department of Medicine, the Royal Hallamshire Hospital, Sheffield, England
,
B W Woodcock
2   The Department of Medicine, the Royal Hallamshire Hospital, Sheffield, England
,
J F Martin
2   The Department of Medicine, the Royal Hallamshire Hospital, Sheffield, England
› Author Affiliations
Further Information

Publication History

Received 26 September 1983

Accepted 06 July 1984

Publication Date:
19 July 2018 (online)

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Summary

Megakaryocyte cytoplasmic volumes were studied in 13 subjects 18 ± 2 days after admittance to the coronary care unit. Seven had suffered a myocardial infarction (MI group) while six had chest pain but no recent infarction. Megakaryocytes were also studied in 10 subjects suffering coronary sudden unexpected death (CSD group) and 11 subjects suffering sudden unexpected un-natural death. There was no significant difference between the megakaryocyte cytoplasmic volume distributions of the MI and CSD groups, although they had a significantly greater mean (p <0.01) and range (p <0.001) than theirrespectivecontrolgroups.

There was no significant difference in platelet volumes observed within 24 hr of the infarct and 18 ± 2 days later. Mean platelet volume was significantly correlated (r = 0.89, p <0.006) to mean megakaryocyte cytoplasmic volume in the MI group. A computer simulation of platelet production showed no significant difference between platelet volumes observed in the MI group and those estimated to be circulating before death in the CSD group.

Keywords

Myocardial infarction - Sudden cardiac death - Megakaryocyte volume - Platelet volume
 

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