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Thromb Haemost 1984; 52(02): 188-190
DOI: 10.1055/s-0038-1661169
DOI: 10.1055/s-0038-1661169
Original Article
Protein C Level at Birth
Further Information
Publication History
Received 12 March 1984
Accepted 20 July 1984
Publication Date:
28 August 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198402/lookinside/thumbnails/10-1055-s-0038-1661169-1.jpg)
Summary
The protein C level was determined, on cord blood, for 30 healtly newborns by electro-immuno assay using a monospecific antiserum. For the newborns the mean level of protein C related antigen is about one third of normal adults’ mean level. There is a good correlation between Protein C related antigen and prothrombin related antigen. The low level of these vitamin-K-dependent proteins is probably a consequence of partial liver immaturity at birth. Using two-dimensional immuno-electrophoresis we were unable to detect subcarboxylated forms of protein C. However these abnormal forms could be seen in vitamin-K deficiencies of neonates.
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References
- 1 Kisiel W. Human plasma protein C: isolation, characterization and mechanism of activation by α-thrombin. J Clin Invest 1979; 64: 761-769
- 2 Femlund P, Stenflo J. Amino acid sequence of the light chain of bovine protein C. J Biol Chem 1982; 257: 12170-12179
- 3 Stenflo J, Femlund P. Amino acid sequence of the heavy chain of bovine protein C. J Biol Chem 1982; 257: 12180-12190
- 4 Kisiel W, Ericsson LH, Davie EW. Proteolytic activation of protein C from bovine plasma. Biochemistry 1976; 15: 4893-4900
- 5 Esmon NL, Owen WG, Esmon CT. J. Biol Chem 1982; 257: 859-864
- 6 Kisiel W, Canfield W, Ericsson L, Davie EW. Anticoagulant properties of bovine protein C following activation by thrombin. Biochemistry 1977; 16: 5824-5831
- 7 Marlar RA, Kleiss AJ, Griffin JH. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood 1982; 59: 1067-1072
- 8 Walker FJ. Regulation of activated protein C by a new protein. A possible function of bovine protein S J Biol Chem 1980; 255: 5521-5524
- 9 Walker FJ. Regulation of activated protein C by protein S. The role of phospholipids in factor Va inactivation J Biol Chem 1981; 256: 11128-11131
- 10 Comp PC, Esmon CT. Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest 1981; 256: 1221-1228
- 11 Esmon CT. Protein C: biochemistry, physiology and clinical implications. Blood 1983; 62: 1155-1158
- 12 Barrowcliffe PW, Thomas DP. Antithrombin III and heparin. In: Bloom AL, Thomas DP. (eds) Haemostasis and thrombosis. Churchill Livingstone; London: 1981. pp 712-724
- 13 Laurell CB. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 1966; 15: 45-52
- 14 Caen J, Larrieu MJ, Samama M. L’Hémostase. L’Expansion Scientifique; Paris: 1975. pp 154-157
- 15 Sokal RR, Rohlf FJ. Biometry. The principles and practice of statistics in biological research. W H Freeman and Co; San Francisco: 1969
- 16 Laurell CB. Antigen-antibody crossed electrophoresis. Anal Biochem 1965; 10: 358-361
- 17 Bettina RM, Broekmans AW, Van derLinden, Mertens K. Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemostas 1982; 48: 1-5
- 18 Malia RG, Preston FE, Michell VE. Evidence against vitamin K deficiency in normal neonates. Thromb Haemostas 1980; 44: 159-160
- 19 Mannucci PM, Vigano S. Deficiencies of protein C, an inhibitor of blood coagulation. Lancet 1982; 2: 463-467
- 20 Corrigan JJ, Kryc JK. Factor II (prothrombin) levels in cord blood: correlation of coagulant activity with immunoreactive protein. J Pediatr 1980; 97: 979-983
- 21 Muntean W, Petek W, Rosanelli K, Mutz ID. Immunologic studies of prothrombin in newborns. Pediat Res 1979; 13: 1262-1265
- 22 Larrieu MJ, Soulier JP, Minkowki A. Le sang du cordon ombilical: étude complète de sa coagulabilité, comparaison avec le sang maternel. Etudes Néonatales 1952; 1: 39-52
- 23 Foloppe B, Delahousse B, Leclerc MH, Moalic P, Gruel Y, Legargasson JF, Leroy J. Variation du taux de la protéine C au cours des cinq premiers jours de la vie du nouveau-né sain à terme.. Réunion du Groupe d’Etudes sur l’Hémostase et la Thrombose, Tours 1984 p 4 (Abstr)