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Thromb Haemost 1984; 52(02): 188-190
DOI: 10.1055/s-0038-1661169
Original Article
Schattauer GmbH Stuttgart

Protein C Level at Birth

B Polack
1   The Laboratoire d’Hématologie, Center Hospitalier Régional et Universitaire, Grenoble, France
,
P Pouzol
1   The Laboratoire d’Hématologie, Center Hospitalier Régional et Universitaire, Grenoble, France
,
J Amiral
2   The Diagnostica Stago, Asnière, France
,
L Kolodie
1   The Laboratoire d’Hématologie, Center Hospitalier Régional et Universitaire, Grenoble, France
› Author Affiliations
Further Information

Publication History

Received 12 March 1984

Accepted 20 July 1984

Publication Date:
28 August 2018 (online)

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Summary

The protein C level was determined, on cord blood, for 30 healtly newborns by electro-immuno assay using a monospecific antiserum. For the newborns the mean level of protein C related antigen is about one third of normal adults’ mean level. There is a good correlation between Protein C related antigen and prothrombin related antigen. The low level of these vitamin-K-dependent proteins is probably a consequence of partial liver immaturity at birth. Using two-dimensional immuno-electrophoresis we were unable to detect subcarboxylated forms of protein C. However these abnormal forms could be seen in vitamin-K deficiencies of neonates.

Keywords

Protein C - Newborn - PIVKA
 

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