Changes in Plasminogen Activator Activity and Plasmin Inhibition in the Pig During Experimental Hypovolaemia

A Smokovitis; M Wagner; M Starlinger; A Opitz; B R Binder

doi:10.1055/s-0038-1661252

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 53(01): 130-133
DOI: 10.1055/s-0038-1661252

Original Article

Schattauer GmbH Stuttgart

Changes in Plasminogen Activator Activity and Plasmin Inhibition in the Pig During Experimental Hypovolaemia

Authors

A Smokovitis

¹The Department of Physiology, Veterinary Faculty, Aristotelian University of Thessaloniki, Greece
M Wagner

²The First Department of Traumatology, Medical School, University of Vienna, Austria
M Starlinger

³The First Department of Surgery, Medical School, University of Vienna, Austria
A Opitz

²The First Department of Traumatology, Medical School, University of Vienna, Austria
B R Binder

⁴The Department of Medical Physiology, Medical School, University of Vienna, Austria

Abstract

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Summary

A markedly decreased plasminogen activator activity (PAA) was seen in lung, heart and kidney after experimental hypovolemia in the pig. In 2 of 12 cases, an increased PAA was found in liver and spleen. In skeletal muscle, skin, sciatic nerve and in 10 of 12 cases in liver and spleen PAA was unchanged. A slightly increased plasmin inhibition was noted only in the lung. These changes in tissue PAA were reflected by an increase in the PAA of euglobulin fractions concomitant with a decrease in antiplasmin activity in the blood samples obtained during the bleeding experiments.

Key words

Haemorrhagic hypotension - Fibrinolysis - Plasminogen activator activity - Plasmin inhibition - Pig

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References

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