HTLV-I Antibody Status in Hemophilia Patients Treated with Factor Concentrates Prepared from U.S. Plasma Sources and in Hemophilia Patients with AIDS

Summary

Serum samples from 85 Austrian hemophilia patients treated with lyophilized factor concentrates prepared from U.S. plasma sources, 24 hemophilia patients from Georgia on a home therapy program with factor concentrates, and 10 U.S. hemophilia patients with acquired immunodeficiency syndrome (AIDS) were analyzed by two different methods for the presence of antibodies to the major internal antigen of human T-cell leukemia virus I (HTLV-I) p²⁴. All but one, a Georgia sample, were negative. The absence of antibody to HTLV-I p²⁴ in the serum of European hemophilia patients, of U.S. hemophilia patients with no symptoms of AIDS, and of U.S. hemophilia patients with AIDS is interpreted as an indication of the lack of ready transmissibility of HTLV-I in lyophilized factor concentrates.

Keywords

HTLV - Hemophilia - Factor concentrates

• References

• 1 Saxinger WC, Gallo RC. Possible risk to recipients of blood from donors carrying serum markers of human T-cell leukaemia virus. Lancet 1982; 1: 1074
• 2 Shimoyama M, Minata K, Tobinai K, Horikoshi N, Ikuba T, Deura K, Nagatani T, Ozaki Y, Inada N, Komoda H, Hinuma Y. Anti-ATLV (antibody to the adult T-cell leukemia cell associated antigen)-positive hematologic malignancies in the Kanto district. Jap J Clin Oncol 1982; 12: 109-116
• 3 Miyoshi I, Fujishita M, Taguchi H, Ohtsuki Y, Akagi T, Morimoto Y, Nagasaki A. Caution against blood transfusion from donors seropositive to adult T-cell leukaemia-associated antigens. Lancet 1982; 1: 683-684
• 4 Okochi K, Sato H, Hinuma Y. A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang 1984; 46: 245-253
• 5 Blattner WA, Kalyanaraman VS, Robert-Guroff M, Lister TA, Galton DA G, Sarin PS, Crawford MH, Catovsky D, Greaves M, Gallo RC. The human type-C retrovirus, HTLV, in blacks from the Caribbean region, and relationship to adult T-cell leukemia/lymphoma. Int J Cancer 1982; 30: 257-264
• 6 Gallo RC, Kalyanaraman VS, Sarngadharan MG, Sliski A, Vonderheid EC, Maeda M, Nakao Y, Yamada K, Ito Y, Gutensohn N, Murphy S, Bunn PA, Catovsky D, Greaves MF, Blayney DW, Blattner W, Jarrett WF H, zur Hausen H, Seligmann M, Brouet JC, Haynes BF, Jegasothy BV, Jaffe E, Cossman J, Broder S, Fisher RI, Golde DW, Robert-Guroff M. Association of the human type C retrovirus with a subset of adult T-cell cancers. Cancer Res 1983; 43: 3892-3899
• 7 Saxinger WC, Gallo RC. Possible risk to recipients of blood from donors carrying serum markers of human T-cell leukaemia virus (letter). Lancet 1982; 1: 1074
• 8 Lee CA, Kemoff PB A, Bofill M, Rizza CR, Downing RG. HTLV and haemophilia. Lancet 1984; 1: 1028
• 9 Blayney DW, Jaffe ES, Blattner WA, Cossman J, Robert-Guroff M, Longo DL, Bunn PA, Gallo RC. The human T-cell leukemia/ lymphoma virus associated with American adult T-cell leukemia/ lymphoma. Blood 1983; 2: 401-405
• 10 Lechner K, Niessner H, Bettelheim P, Deutsch E, Fasching I, Fuhrmann M, Hinterberger W, Korninger C, Neumann E, Liszka K, Knapp W, Mayr WR, Stingl G, Zeitlhuber U. T-cell alternations in hemophiliacs treated with commercial clotting factor concentrates. Thromb Haemostas 1983; 50: 552-556
• 11 Kalyanaraman VS, Cabradilla CD, Getchell JP, Narayanan R, Braff EH, Chermann JC, Barre-Sinoussi F, Montagnier L, Spira TJ, Kaplan J, Fishbein D, Jaffe HW, Curran JW, Francis DP. Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS. Science 1984; 225: 321-323
• 12 Kalyanaraman VS, Sarngadharan MG, Nakao Y, Ito Y, Aoki T, Gallo RC. Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan. Proc Natl Acad Sci USA 1982; 79: 1653-1657
• 13 Tsang VC W, Peralta JM, Simons AR. The enzyme-linked immunoelectro-transfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis. Methods Enzymol 1983; 92: 377-391
• 14 Kalyanaraman VS, Sarngadharan MG, Poiesz BJ, Ruscetti FW, Gallo RC. Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses. J Virol 1981; 38: 906-915
• 15 Popovic M, Sarin PS, Robert-Guroff M, Kalyanaraman VS, Mann D, Minowada J, Gallo RC. Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 1983; 219: 856-859
• 16 Clapham P, Nagy K, Cheingsong-Popov R, Exley M, Weiss RA. Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science 1983; 222: 1125-1127
• 17 Miyoshi I, Taguchi H, Kubonishi I, Yoshimoto S, Ohtsuki Y, Shiraishi Y, Akagi T. Type C virus-producing cell lines derived from adult T- cell leukemia. In: Adult T-cell leukemia and related diseases. Hanaoka M, Takatsuki K, Shimoyama M. (eds) Plenum Press; New York: 1982. pp 219-228
• 18 Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 1984; 224: 500-502
• 19 Vilmer E, Rouzioux C, Vezinet Brun F, Fischer A, Chermann JC, Barre-Sinoussi F, Gazengel C, Dauguet C, Manigne P, Griscelli C, Montagnier L. Isolation of new lymphotropic retrovirus from two siblings with haemophilia B, one with AIDS. Lancet 1984; 1: 753-757
• 20 Chermann JC, Barre-Sinoussi F, Montagnier L. Characterization and possible role in AIDS of a new human T-lymphotropic retrovirus. In Acquired immune deficiency syndrome. Gottlieb MS, Groopman JE. (eds) pp 31-46 Alan R.Liss Inc.; New York: 1984
• 21 Feorino PM, Kalyanaraman VS, Haverkos HW, Cabradilla CD, Warfield DT, Jaffe HW, Harrison AK, Gottlieb MS, Goldfinger D, Chermann JC, Barre-Sinoussi F, Spira TJ, McDougal JS, Curran JW, Montagnier L, Murphy FA, Francis DP. Lymphadenopathy-associated virus infection of a blood donor-recipient pair with acquired immunodeficiency syndrome. Science 1984; 225: 69-72
• 22 Ramsey RB, Palmer EL, McDougal JS, Kalyanaraman VS, Jackson DW, Chorba TL, Holman RC, Evatt BL. Antibody to lymphadenopathy-associated virus in haemophiliacs with and without AIDS (letter). Lancet 1984; 2: 397-398
• 23 Palmer EL, Ramsey RB, Feorino PF, Harrison AK, Cabradilla C, Francis DP, Poon M-C, Evatt BL. Isolation of HTLV from lymphocytes of two hemophiliacs with AIDS. Ann Intern Med 1984; 101: 293-297
• 24 Clauvel JP, Brouet JC, Maissonneuve P, Perol Y, Sultan Y. Etude des sous-populations lymphocytaires chez l’hémophile. Presse Med 1984; 13: 19-22
• 25 Hanaoka M. Disease entity of adult T-cell leukemia: cytological aspects and geographic pathology. In Adult T-cell leukemia and related diseases. Hanaoka M, Takatsuki K, Shimoyama M. (eds) Plenum Press; New York: 1982. pp 1-2
• 26 Blattner WA, Blayney DW, Robert-Guroff M, Sarngadharan MG, Kalyanaraman VS, Sarin PS, Jaffe ES, Gallo RC. Epidemiology of human T-cell leukemia/lymphoma virus. J Infect Dis 1983; 147: 406-416
• 27 Robert-Guroff M, Kalyanaraman VS, Blattner WA, Popovic M, Sarngadharan MG, Maeda M, Blayney D, Catovsky D, Bunn PA, Shibata A, Nakao Y, Ito Y, Aoki T, Gallo RC. Evidence for human T-cell lymphoma/leukemia virus infection of family members of human T-cell leukemia/lymphoma patients. J Exp Med 1983; 157: 248-258