Download PDF
Thromb Haemost 1985; 53(02): 198-199
DOI: 10.1055/s-0038-1661272
Original Article
Schattauer GmbH Stuttgart

Effects of Oral Contraceptives and Obesity on Protein C Antigen

T W Meade
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK
,
Y Stirling
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK
,
H Wikes
1   The British Heart Foundation Cardiovascular Epidemiology Research Group, Northwick Park Hospital, Harrow, UK
,
P M Mannucci
2   The Haemophilia and Thrombosis Centre, Angelo Bianchi Bonomi, University of Milan, Italy
› Author Affiliations
Further Information

Publication History

Received 13 September 1984

Accepted 10 December 1984

Publication Date:
18 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

In 24 women using oral contraceptives, protein C antigen was higher than in 24 women of the same age and of the same degree of obesity who were not using OC. In the pooled data for all 48 women, there was an increase in protein C of about 1% (of standard) for each 1.0 mm increase in skinfold thickness. Protein C tends to be high rather than low in circumstances predisposing to thrombosis.

Keywords

Oral contraceptives - Protein C - Obesity
 

  • References

  • 1 Broekmans AW, Veltkamp JJ, Bertina R. Congenital protein C deficiency and venous thromboembolism. N Engl J Med 1983; 309: 340-344
    CrossrefPubMedSearch in Google Scholar
  • 2 Griffin JH, Evatt B, Zimmerman T, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-1373
    CrossrefPubMedSearch in Google Scholar
  • 3 Meade TW. Epidemiology of atheroma and thrombosis. In Haemostasis and Thrombosis. Bloom AL, Thomas DP. (Eds) Churchill Livingstone; 1981. pp 575-592
    Search in Google Scholar
  • 4 Meade TW, North WR S, Chakrabarti R, Haines AP, Stirling Y. Population-based distributions of haemostatic variables. Br Med Bull 1977; 33: 238-288
    PubMedSearch in Google Scholar
  • 5 Mannucci PM, Vigano S. Déficiences of Protein C, an inhibitor of blood coagulation. Lancet 1982; 2: 463-467
    PubMedSearch in Google Scholar
  • 6 Brozovic M, Stirling Y, Harricks C, North WR S, Meade TW. Factor VII in an industrial population. Br J Haematol 1974; 28: 381-391
    CrossrefPubMedSearch in Google Scholar
  • 7 Meade TW, Chakrabarti R, Haines AP, Howarth DJ, North WR S, Stirling Y. Haemostatic, lipid and blood pressure profiles of women on oral contraceptives containing 50 μg or 30 μg oestrogen. Lancet 1977; 2: 948-951
    PubMedSearch in Google Scholar
  • 8 Viganò S, Mannucci PM, D’Angelo A, Gelfi C, Gensini GF, Rostagno C, Neri Serneri GG. Protein C antigen is not an acute phase reactant and is often high in ischemic heart disease and diabetes. Thromb Haemostas 1984; 52: 263-266
    PubMedSearch in Google Scholar
  • 9 O’Connor NT J, Broekmans AW, Bertina RM. Protein C values in coronary artery disease. Br Med J 1984; 2: 1192
    PubMedSearch in Google Scholar