Summary
Previously, we demonstrated that in vivo regulation of liver fibrinogen synthesis
occurs via the fibrinogen mRNA level. However, the molecular regulatory mechanism
of fibrinogen synthesis is still not well understood. Fibrinogen or fibrin degradation
products might play an important role in regulating fibrinogen synthesis. In our present
study, we have injected rats intraperitoneally with purified homologous fragments
and measured the liver content of mRNA specific coding for fibrinogen. Increased levels
of fibrinogen mRNA and elevated plasma fibrinogen concentrations were observed in
rats after administration of fibrinogen degradation products X, Y, DEGTA Dcate or E. Fragment E or E’ has a less stimulatory effect than X, Y or Dcate, whereas cross-linked fibrin degradation product D dimer does not increase fibrinogen
synthesis. This article reports for the first time a stimulatory effect of the high
molecular weight fibrinogen degradation products on fibrinogen synthesis.
Keywords
Fibrinogen mRNA - Fibrinogen synthesis - Fibrinogen fragments - Fibrin degradation
products - Isolated hepatocytes
