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Thromb Haemost 1985; 53(03): 293-296
DOI: 10.1055/s-0038-1661299
Original Article
Schattauer GmbH Stuttgart

Severe Protein C Deficiency in Congenital Thrombotic Disease – Description of an Immunoenzymological Assay for Protein C Determination

J Soria
The Services des Professeurs Bernadou, Fabiani, Samama, Hôtel-Dieu, Paris, the Services des Professeurs Caen et Rousselet, Hôpital Lariboisière, Paris
,
C Soria
The Services des Professeurs Bernadou, Fabiani, Samama, Hôtel-Dieu, Paris, the Services des Professeurs Caen et Rousselet, Hôpital Lariboisière, Paris
,
M Samama
The Services des Professeurs Bernadou, Fabiani, Samama, Hôtel-Dieu, Paris, the Services des Professeurs Caen et Rousselet, Hôpital Lariboisière, Paris
,
G Nicolas
1   The C.H.U., Nantes, France
The Services des Professeurs Bernadou, Fabiani, Samama, Hôtel-Dieu, Paris, the Services des Professeurs Caen et Rousselet, Hôpital Lariboisière, Paris
,
W Kisiel
2   The University of Washington, Seattle, Washington, USA
The Services des Professeurs Bernadou, Fabiani, Samama, Hôtel-Dieu, Paris, the Services des Professeurs Caen et Rousselet, Hôpital Lariboisière, Paris
› Author Affiliations
Further Information

Publication History

Received 01 June 1983

Accepted 03 April 1984

Publication Date:
18 July 2018 (online)

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Summary

An immunoenzymatic assay (ELISA) is described for the quantitative assay of protein C in plasma. This technique allows a safe, reliable, and sensitive assay of protein C, and is easily used for routine investigation. Using this technique, a protein C deficiency (0.16 U/ml) was discovered in a 16 year old patient with a history of very severe thrombotic disease. Protein C deficiency was also discovered in his mother (0.62 U/ml) and father (0.50 U/ml). We therefore suggest that this case could represent a homozygous deficiency of protein C.

Keywords

Protein C - Protein C deficiency - Thrombotic disease