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Thromb Haemost 1985; 53(03): 303-305
DOI: 10.1055/s-0038-1661302
Original Article
Schattauer GmbH Stuttgart

The Effect of the Synthetic Steroid ORG OD14 on Fibrinolysis and Blood Lipids in Postmenopausal Women

Isobel D Walker
1   The Department of Haematology, Royal Infirmary, Glasgow, UK
,
J F Davidson
1   The Department of Haematology, Royal Infirmary, Glasgow, UK
,
A Richards
2   The Department of Gynaecology, Royal Infirmary, Glasgow, UK
,
R Yates
2   The Department of Gynaecology, Royal Infirmary, Glasgow, UK
,
H P McEwan
2   The Department of Gynaecology, Royal Infirmary, Glasgow, UK
› Author Affiliations
Further Information

Publication History

Received 01 June 1984

Accepted 07 February 1985

Publication Date:
18 July 2018 (online)

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Summary

Two groups of postmenopausal women were compared. One group of 13 was given the synthetic steroid Org OD14 to suppress climacteric symptoms and one group of 14 was given placebo. After a 2 week baseline period the subjects received daily for 12 weeks, either 2.5 mg Org OD14 or placebo. There were no significant differences between the groups pre-treatment. Compared with the placebo group, during treatment, the Org OD14 group showed the following significant differences: higher haemoglobin, haematocrit, platelet count, plasminogen, fibrinolytic activity on fibrin plates and antithrombin III and lower fibrinogen. No significant differences between the groups were found in α2 antiplasmin levels, total cholesterol, total triglycerides, bilirubin or transaminase levels but the Org OD14 group had significantly lower levels of HDL cholesterol. With the exception of the haemoglobin and haematocrit levels all of the differences had disappeared by 2 weeks post treatment.

Keywords

Synthetic steroid - Anabolic steroid effect - Fibrinolysis - Blood lipids - Antithrombin III - Plasminogen - Fibrinogen
 

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