Persistence and Progression of Immunologic Abnormalities in Haemophilia

Joan C Gill; Dana Wheeler; Jay E Menitove; Richard H Aster; James T Casper; Phyllis Kirchner; Robert R Montgomery

doi:10.1055/s-0038-1661308

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 53(03): 328-331
DOI: 10.1055/s-0038-1661308

Original Article

Schattauer GmbH Stuttgart

Persistence and Progression of Immunologic Abnormalities in Haemophilia

Authors

Joan C Gill

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
Dana Wheeler

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
Jay E Menitove

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
Richard H Aster

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
James T Casper

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
Phyllis Kirchner

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
Robert R Montgomery

The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA

Abstract

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Summary

Immunologic parameters in 51 patients with haemophilia treated with cryoprecipitate from volunteer donors or with commercial lyophilized concentrate were studied on 2–7 occasions. Concentrate users had significantly decreased mean T4 (helper)/T8 (suppressor) lymphocyte ratios when the initial (1.5 ± .43) and most recent (1.25 ± .60) values were compared (p <.001), whereas in cryoprecipitate users mean values remained normal. Of the 22 concentrate users with initially normal T4/T8 ratios, 10 became abnormal during the study, an incidence of 45%. Fifteen of 28 (54%) patients with abnormal T4/T8 ratios had elevated circulating immune complexes (CIC), whereas all 16 patients with normal T4/T8 ratios had normal levels of CIC. Six patients have persistent lymphadenopathy.

Keywords

Haemophilia - Acquired immune deficiency - Immune complexes - Lymphocyte subsets - Therapeutic clotting factor replacement

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References

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