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Thromb Haemost 1985; 53(03): 343-345
DOI: 10.1055/s-0038-1661311
Original Article
Schattauer GmbH Stuttgart

Percutaneous Treatment with a Mucopolysaccharide Polysulphate of Experimentally Induced Subcutaneous Haematomas in Man

B Larsson
The Department of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Huddinge University Hospital, Huddinge, Sweden
,
S Fianu
The Department of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Huddinge University Hospital, Huddinge, Sweden
,
A Jonasson
The Department of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Huddinge University Hospital, Huddinge, Sweden
,
B Forsskåhl
The Department of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Huddinge University Hospital, Huddinge, Sweden
› Author Affiliations
Further Information

Publication History

Received 10 October 1984

Accepted 07 March 1985

Publication Date:
18 July 2018 (online)

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Summary

In a double blind trial on ten healthy volunteers, the efficacy of a topically applied mucopolysaccharide polysulphate[*] in the treatment of subcutaneous haematomas was assessed. Standardized haematomas were induced by subcutaneous injection of a mixture of autogenous blood and 125I-fibrinogen. The absorption of the haematoma, expressed as the removal of the labelled fibrin(ogen), could thus be objectively measured by the decrease in radioactivity.

The results show an exponential absorption of these haematomas. The absorption time was reduced to about half compared with placebo, when treated topically with mucopolysaccharide polysulphate. The difference is statistically highly significant and is also considered clinically relevant.

Keywords

Haematoma absorption - 125I-fibrinogen - Topical treatment

*Hirudoid® cream, manufacturer Luitpold-Werk, Munich, FRG

*Hirudoid® cream. Luitpold-Werk, Munich, FRG


 

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