Smooth Muscle Proliferation in Chronically Injured Canine Pulmonary Arteries Is Reduced by a Potent Platelet Aggregation Inhibitor U-53,059

Robert G Schaub; James C Keith Jr; Carol A Simmons; Clarence A Rawlings

doi:10.1055/s-0038-1661313

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1985; 53(03): 351-355
DOI: 10.1055/s-0038-1661313

Original Article

Schattauer GmbH Stuttgart

Smooth Muscle Proliferation in Chronically Injured Canine Pulmonary Arteries Is Reduced by a Potent Platelet Aggregation Inhibitor U-53,059

Autoren

Robert G Schaub

¹The Department of Atherosclerosis and Thrombosis Research, The Upjohn Company, Kalamazoo, MI, USA
James C Keith Jr

²The Department of Veterinary Biology, Virginia Polytechnical Institute, Blacksburg, VA, USA
Carol A Simmons

¹The Department of Atherosclerosis and Thrombosis Research, The Upjohn Company, Kalamazoo, MI, USA
Clarence A Rawlings

³The Department of Small Animal Medicine, The University of Georgia, Athens, GA, USA

Abstract

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Summary

Dirofilaria immitis (DI) infection chronically injures canine pulmonary arteries. This injury produces endothelial cell loss, platelet/leukocyte adhesion, and smooth muscle proliferation. In the present study we assessed the effect of the cyclooxygenase inhibitor, U-53,059, on platelet function, platelet kinetics, coagulation, and smooth muscle proliferation in DI infected dogs.

Platelet aggregation to the combination of arachidonic acid/ ADP was significantly inhibited by U-53,059. Coagulation and hematologic parameters were not effected by either DI infection or U-53,059 treatment. Platelet survival and the number of platelet dense granules were reduced in DI infection. Quantification of the lesions demonstrated that U-53,059 reduced both severity and density compared to non-treated dogs. U-53,059 is a potent and effective inhibitor of platelet aggregation which modifies smooth muscle proliferation produced by chronic vascular injury.

Keywords

Platelets - Myointimal proliferation - Vascular injury

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Referenzen

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