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Thromb Haemost 1985; 53(03): 401-403
DOI: 10.1055/s-0038-1661323
Original Article
Schattauer GmbH Stuttgart

Vitamin K Dependent Proteins in Fetal Hemostasis at Mid Trimester of Pregnancy

F Forestier
The Centre de Diagnostic Prénatal et de Foetologie, Hôpital Notre Dame de Bon-Secours, Paris, France
,
F Daffos
The Centre de Diagnostic Prénatal et de Foetologie, Hôpital Notre Dame de Bon-Secours, Paris, France
,
M Rainaut
The Centre de Diagnostic Prénatal et de Foetologie, Hôpital Notre Dame de Bon-Secours, Paris, France
,
Y Solé
The Centre de Diagnostic Prénatal et de Foetologie, Hôpital Notre Dame de Bon-Secours, Paris, France
,
J Amiral
1   The Laboratoire STAGO, Franconville, France
› Author Affiliations
Further Information

Publication History

Received 04 October 1985

Accepted 22 March 1985

Publication Date:
21 August 2018 (online)

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Summary

The vitamin K dependent coagulation factor activities were measured in 63 normal human fetuses from 19 to 28 weeks of pregnancy. These activities were included between 9 to 28 percent of normal adult levels.

Prothrombin antigen, factor IX antigen and protein C were also measured. There is a good correlation between prothrombin procoagulant activity and antigenicity, suggesting that low level of these vitamin K dependent proteins in fetuses is probably a consequence of liver immaturity.

Keywords

Haemostasis - Fetus - Vitamin K
 

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