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Semin Liver Dis 2018; 38(03): 252-259
DOI: 10.1055/s-0038-1661371
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Emerging Importance of Liver Sinusoidal Endothelial Cells in Regulating Injury during Machine Perfusion of Deceased Liver Donors

Ricky H. Bhogal
1   Centre for Liver Research, Institute for Biomedical Research, University of Birmingham College of Medical and Dental Sciences, The Medical School, Birmingham, United Kingdom
,
Hynek Mergental
1   Centre for Liver Research, Institute for Biomedical Research, University of Birmingham College of Medical and Dental Sciences, The Medical School, Birmingham, United Kingdom
,
Darius F. Mirza
1   Centre for Liver Research, Institute for Biomedical Research, University of Birmingham College of Medical and Dental Sciences, The Medical School, Birmingham, United Kingdom
,
Simon C. Afford
1   Centre for Liver Research, Institute for Biomedical Research, University of Birmingham College of Medical and Dental Sciences, The Medical School, Birmingham, United Kingdom
› Author Affiliations
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Publication History

Publication Date:
24 July 2018 (online)

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Abstract

While majority of liver transplants worldwide continue to be performed using deceased donor organs, the demands for donor livers continues to exceed the current supply. In an attempt to maximize the number of potentially usable donor livers and expand the current donor pool, there is intense global research by various groups exploring the role of machine perfusion in the liver transplantation, particularly with respect to the machine perfusion of extended-criteria liver donors. In this review, the authors summarize the current field of machine perfusion strategies as applied to deceased donor liver transplantation and how therapeutic targeting of the liver sinusoidal endothelial cell may improve the quality of donor livers.

Keywords

liver transplantation - liver sinusoidal endothelial cells - machine perfusion - donor liver - ischemia-reperfusion injury
 

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