Effects of Arginine Vasopressin (AVP) Infusions on Circulating Concentrations of Platelet AVP, Factor VIII: C and von Willebrand Factor

S S Nussey; D H Bevan; V T Y Ang; J S Jenkins

doi:10.1055/s-0038-1661441

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1986; 55(01): 034-036
DOI: 10.1055/s-0038-1661441

Original Article

Schattauer GmbH Stuttgart

Effects of Arginine Vasopressin (AVP) Infusions on Circulating Concentrations of Platelet AVP, Factor VIII: C and von Willebrand Factor

Authors

S S Nussey

The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
D H Bevan

The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
V T Y Ang

The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
J S Jenkins

The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK

Abstract

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Summary

To study the possible role of arginine vasopressin (AVP) in the control of haemostasis AVP infusions at 3 doses (0.1, 0.2 and 0.3 mU/kg/min) were performed in 6 male volunteers. Both plasma and platelet AVP concentrations rose in a dose-related manner. At doses of 0.2 and 0.3 mU/kg/min there was an increase in the plasma concentrations of both plasma Factor VIII and von Willebrand factor. The data support the hypothesis that AVP, by interacting with platelets and stimulating factor VIII and von Willebrand factor release, plays a role in the control of haemostasis.

Key words

Arginine vasopressin - Platelets - Factor VIII - von Wille-brand factor

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References

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