Thromb Haemost 1986; 55(01): 054-057
DOI: 10.1055/s-0038-1661446
Original Article
Schattauer GmbH Stuttgart

The Influence of DDAVP Infusion on the Coagulation and Fibrinolytic Response to Surgery

E Melissari
The Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, UK
,
M F Scully
The Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, UK
,
V Paes
The Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, UK
,
V Ellis
The Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, UK
,
V V Kakkar
The Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, UK
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 18. April 1985

Accepted 21. Oktober 1985

Publikationsdatum:
19. Juli 2018 (online)

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Summary

The response of components of the coagulation and fibrinolysis systems to infusion of DDAVP has been examined in patients undergoing elective surgery. In the DDAVP treated group there was a significant increase, compared to control, in plasminogen activator (by fibrin plates p <0.005, ECLT p <0.0125, by Student’s t test) before operation. No difference between groups was seen by either methods in the activator levels in samples 24 h postoperation, whereas a significant drop (p <0.002) in protein C concentration was observed at this stage in the treated group. Levels of factor VIII components were significantly higher (p <0.005) than control at all stages of operation and a significant shortening (5 sec p <0.05) of the APTT was seen at all stages (apart from 24 h samples). DDAVP infusion therefore may exacerbate the hypercoagulable state observed in surgical patients without preventing the (post-operatively) fibrinolytic shutdown. Instead, infusion tends to produce fibrinolytic depletion at the key mid-operative stage.