Blood Platelet Plasminogen Activator Inhibitor: Two Different Pools of Endothelial Cell Type Plasminogen Activator Inhibitor in Human Blood

E D Sprengers; J W N Akkerman; B G Jansen

doi:10.1055/s-0038-1661556

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1986; 55(03): 325-329
DOI: 10.1055/s-0038-1661556

Original Article

Schattauer GmbH Stuttgart

Blood Platelet Plasminogen Activator Inhibitor: Two Different Pools of Endothelial Cell Type Plasminogen Activator Inhibitor in Human Blood

Authors

E D Sprengers

¹The TNO Gaubius Institute for Cardiovascular Research, Leiden, The Netherlands
J W N Akkerman

²The Department of Haematology, University Hospital Utrecht, Utrecht, The Netherlands
B G Jansen

¹The TNO Gaubius Institute for Cardiovascular Research, Leiden, The Netherlands

Abstract

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Summary

An assay for plasminogen activator inhibitor in human platelets is described. With this assay we find an average value of 6.8 × 10⁻⁸ IU/platelet (S.D. = 3.0 × 10⁻⁸; n = 20) in a healthy population. We characterized the PA-inhibitor from platelets and identified it as endothelial cell type plasminogen activator inhibitor, by its immunologic and functional properties. Besides the plasma pool of plasminogen activator inhibitor with a very high turnover rate, platelets constitute a second pool of plasminogen activator inhibitor in the circulation of the same order of magnitude. The two different pools of plasminogen activator inhibitor might have a different physiologic function.

Keywords

Fibrinolysis - Platelets - Plasminogen activator inhibitor Summary

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References

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