Differential Effects of Oral Low-Dose Aspirin on Prostacyclin Synthesis by Saphenous or Mesenteric Venous Tissues

• References

• 1 Hanley SP, Bevan J, Cockbill SR, Heptinstall S. Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis. Lancet 1981; 1: 969-971
• 2 Weksler BB, Pett SB, Alonso D. et al Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients. N Engl J Med 1983; 308: 800-805
• 3 Hanley SP, Bevan J. Inhibition by aspirin of human arterial and venous prostacyclin synthesis. Prostaglandins Leukotrienes Med 1985; 20: 141-149
• 4 Siebert DJ, Bochner F, Imhoff DM. et al Aspirin kinetics and platelet-aggregation in man. Clin Pharmacol Ther 1983; 33: 367-374
• 5 Cerletti C, Latini R, Del Maschio A, Galletti F, Dejana E, de Gaetano G. Aspirin kinetics and inhibition of platelet thromboxane generation-Relevance for a solution of the ‘aspirin dilemma’. Thromb Haemostas 1985; 53: 415-418
• 6 Pedersen AK, FitzGerald GA. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclo-oxygenase. N Engl J Med 1984; 311: 1206-1211
• 7 Dejana E, Costantini V, de Amicis G, Cerletti C, Lorenzi G, de Gaetano G. Differential saiicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy. Proc Soc Exp Biol Med 1985; 180: 533-537
• 8 Cerletti C, Gambino MC, Garattini S, de Gaetano G. Differential inhibition of prostacyclin synthesis in portal vein and aorta after intraduodenal (i. d.), but not i. v. aspirin administration. Blood 1985; 66 (Suppl. 01) 302a