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Thromb Haemost 1986; 56(02): 229-231
DOI: 10.1055/s-0038-1661646
Original Article
Schattauer GmbH Stuttgart

Urinary Beta-Thromboglobulin Correlates with Impairment of Renal Function in Patients with Diabetic Nephropathy

A H Hopper
The University Department of Medicine, The General Infirmary, Leeds, UK
,
H Tindall
The University Department of Medicine, The General Infirmary, Leeds, UK
,
J A Davies
The University Department of Medicine, The General Infirmary, Leeds, UK
› Author Affiliations
Further Information

Publication History

Received 13 August 1985

Accepted after revision 28 July 1986

Publication Date:
20 July 2018 (online)

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Summary

TBeta-thromboglobulin (βTG) is a platelet-specific protein and since its concentration in plasma rises when platelets are activated, it has been used as an indicator of platelet involvement in vascular disease. Since platelets might be involved in the pathogenesis of diabetic microvascular disease we measured urinary βTG in 20 insulin-dependent diabetics with nephropathy and compared the results with those from 20 normal subjects. Measurement of βTG in urine was undertaken to avoid errors induced by blood sampling and to gain information over a prolonged period using a single assay. Measurements were made of βTG, β2-microglobulin and total protein in urine collected for 24 h and creatinine and β2 microglobulin in plasma. Survival of indium-111-labelled platelets was measured in nine patients. Urinary PTG was significantly (p <0.02) increased in the 20 patients compared with 20 normal volunteers (median value 1.3 vs 0.8 μg/24 h). There was a strong correlation between urinary βTG excretion and plasma creatinine concentration (r = 0.8, p <0.0001) and plasma β2-microglobulin concentration (r = 0.9, p <0.0001). Urinary βTG concentration did not correlate with platelet survival. The results indicate that although urinary βTG is significantly increased in patients with diabetic nephropathy its concentration in urine correlates with indicators of glomerular filtration rather than with a test of platelet activation.

Key words

Urinary beta-thromboglobulin - Diabetic nephropathy
 

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