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Thromb Haemost 1983; 50(03): 669-670
DOI: 10.1055/s-0038-1665283
Original Article
Schattauer GmbH Stuttgart

The Effect of Two Low Doses of Aspirin on Whole Blood Thromboxane and Prostacyclin Generation in Healthy Subjects

G Davì
The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
,
N Custro
The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
,
S Novo
The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
,
A Mattina
The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
,
A Strano
The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
› Author Affiliations
Further Information

Publication History

Received 21 February 1983

Accepted 13 July 1983

Publication Date:
18 July 2018 (online)

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Summary

The effects of two low doses of aspirin (20 mg and 100 mg) on prostacyclin and thromboxane formation during whole blood clotting were studied in 8 healthy volunteers.

A single 100 mg aspirin dose caused more than 90% reduction of both serum TXB2 and 6-keto-PGF1α; a single 20 mg dose of aspirin inhibited serum TXB2 more than 6-keto-PGF1α but effects on these two products could not be completely dissociated.

However, the effect of a single 20 mg aspirin dose on serum TXB2, was of much longer duration than its inhibitory effect on PGI2 synthesis during whole blood clotting.

Keywords

Thromboxane - Prostacyclin - Aspirin
 

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