The Effect of Two Low Doses of Aspirin on Whole Blood Thromboxane and Prostacyclin Generation in Healthy Subjects

G Davì; N Custro; S Novo; A Mattina; A Strano

doi:10.1055/s-0038-1665283

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1983; 50(03): 669-670
DOI: 10.1055/s-0038-1665283

Original Article

Schattauer GmbH Stuttgart

The Effect of Two Low Doses of Aspirin on Whole Blood Thromboxane and Prostacyclin Generation in Healthy Subjects

Authors

G Davì

The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
N Custro

The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
S Novo

The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
A Mattina

The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy
A Strano

The Institute of Clinical Medicine and Medical Pathology R, University of Palermo, Italy

Abstract

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Summary

The effects of two low doses of aspirin (20 mg and 100 mg) on prostacyclin and thromboxane formation during whole blood clotting were studied in 8 healthy volunteers.

A single 100 mg aspirin dose caused more than 90% reduction of both serum TXB₂ and 6-keto-PGF_1α; a single 20 mg dose of aspirin inhibited serum TXB₂ more than 6-keto-PGF_1α but effects on these two products could not be completely dissociated.

However, the effect of a single 20 mg aspirin dose on serum TXB₂, was of much longer duration than its inhibitory effect on PGI₂ synthesis during whole blood clotting.

Keywords

Thromboxane - Prostacyclin - Aspirin

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References

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