Download PDF
Thromb Haemost 1991; 65(05): 624-626
DOI: 10.1055/s-0038-1665535
Scientific and Standardization Committee Communications
Schattauer GmbH Stuttgart

Inventory of Exogenous Inhibitors of Platelet Aggregation

For the Subcommittee on Nomenclature of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
Che-Ming Teng
The Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
,
Tur-Fu Huang
The Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • REFERENCES

  • 1 Ouyang C, Huang TF. Platelet aggregation inhibitor from Trimeresurus gramineus snake venom. Biochim Biophys Acta 1983; 757: 332-341
    CrossrefPubMedGoogle Scholar
  • 2 Huang TF, Ouyang C. Action mechanism of the potent platelet aggregation inhibitor from Trimeresurus gramineus snake venom. Thromb Res 1984; 33: 124-138
    PubMedGoogle Scholar
  • 3 Ouyang C, Yeh HI, Huang TF. A potent platelet aggregation inhibitor purified from Agkistrodon halys (Mamushi) snake venom. Toxicon 1983; 21: 797-804
    CrossrefPubMedGoogle Scholar
  • 4 Huang TF, Yeh HI, Ouyang C. Mechanism of action of the platelet aggregation inhibitor purified from Agkistrodon halys (Mamushi) snake venom. Toxicon 1984; 22: 243-251
    CrossrefPubMedGoogle Scholar
  • 5 Huang TF, Wu YJ, Ouyang C. Characterization of a potent platelet aggregation inhibitor from Agkistrodon rhodostoma snake venom. Biochim Biophys Acta 1987; 925: 248-257
    CrossrefPubMedGoogle Scholar
  • 6 Ouyang C, Ma YH, Jih HC, Teng CM. Characterization of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. Biochim Biophys Acta 1985; 841: 1-7
    CrossrefPubMedGoogle Scholar
  • 7 Teng CM, Ma YH, Ouyang C. Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. Biochim Biophys Acta 1985; 841: 8-14
    CrossrefPubMedGoogle Scholar
  • 8 Huang TF, Holt JC, Lukasiewicz H, Niewiarowski S. Trigramin, a low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb/IIIa complex. J Biol Chem 1987; 262: 16157-16163
    PubMedGoogle Scholar
  • 9 Huang TF, Holt JC, Kirby EP, Niewiarowski S. Trigramin: primary strucutre and its inhibition on von Willebrand factor binding to glycoprotein IIb/IIIa complex on human platelets. Biochemistry 1989; 28: 661-666
    CrossrefPubMedGoogle Scholar
  • 10 Hynes RO. Integrins. A family of cell surface receptors. Cell 1987; 48: 549-554
    CrossrefPubMedGoogle Scholar
  • 11 Huang TF, Liu CZ, Ouyang C. Halysin, a potent aggregation inhibitor, inhibits the fibrinogen binding to the activated platelets, Abstract 112. XII Int Congr on Thrombosis and Haemostasis, Tokyo, 1989. Thromb Haemostas 1989 62. 48
    PubMedGoogle Scholar
  • 12 Huang TF, Wang WJ, Ouyang C. Arietin, a snake venom peptide, inhibits platelet aggregation by acting as fibrinogen receptor antagonist of the activated human platelets, Abstract 522. XI Int Congr of Pharmacology, Amsterdam 1990
    PubMedGoogle Scholar
  • 13 Sheu JR, Huang TF. Flavoridin, a potent aggregation inhibitor, purified from Trimeresurus flavoviridis snake venom, Abstract 57. The Fifth Joint Annu Conf of Biomedical Sciences, Taipei 1990
    PubMedGoogle Scholar
  • 14 Huang TF, Liu CZ, Wang WJ, Ouyang C. Characterization of the trigramin-like peptide from snake venoms, the specific antagonists of the fibrinogen receptor on human platelets, Abstract 54. Int Sci Symp on Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis, Taipei 1989
    PubMedGoogle Scholar
  • 15 Chao BH, Jakubowski JA, Savage B, Chow EP, Marzec UM, Harker LA, Maraganore JM. Agkistrodon piscvorus piscvorus platelet aggregation inhibitor of platelet activation. Proc Natl Acad Sci USA 1989; 86: 8050-8054
    CrossrefPubMedGoogle Scholar
  • 16 Gan ZR, Gould RJ, Jacobs JW, Friedman PA, Polokoff MA. Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus. J Biol Chem 1988; 263: 19827-19832
    PubMedGoogle Scholar
  • 17 Knudsen KA, Tuszynski GP, Huang TF, Niewiarowski S. Trigramin, an RGD-containing peptide from snake venom, inhibits cell-sub-stratum adhesion of human melanoma cells. Exp Cell Res 1988; 179: 42-49
    CrossrefPubMedGoogle Scholar
  • 18 Niewiarowski S, Rucinski B, Huang TF, Williams JA, Holt JC, Tuszynski GP, Knudsen KA. Inhibition of fibronectin-integrin interaction by RGD-containing peptides from viper venoms. Gordon Conf on Fibronectin; Oxnard, CA: 1989
  • 19 Cook JC, Huang TF, Rucinski B, Stryzewski M, Tuma RF, Williams JA, Niewiarowski S. Inhibition of platelet hemostatic plug formation by trigramin, a novel “RGD-Peptide”. Am J Physiol 1989; 256: H1038-H1043
    PubMedGoogle Scholar
  • 20 Shebuski RJ, Ramjit DR, Bencen GH, Polokoff MA. Characterization and platelet inhibitory activity of Bitistatin, a potent arginine-glycine-aspartic acid-containing peptide from the venom of the viper Bitis arietans. J Biol Chem 1989; 264: 21550-21556
    PubMedGoogle Scholar
  • 21 Williams J, Rucinski B, Holt J, Niewiarowski S. Elegantin and Albolabrin purified peptides from viper venom; homologies with the RGD domain of fibrinogen and von Willebrand Factor. Biochim Biophys Acta 1990; 1039: 81-89
    CrossrefPubMedGoogle Scholar
  • 22 Rucinski B, Niewiarowski S, Holt JC, Musial J, Knudsen K. Flavoridin. A potent inhibitor of platelet aggregation and cell adhesion, from venom of T. flavoviridis, Abstract 56. Int Sci Symp on Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis, Taipei 1989
    PubMedGoogle Scholar
  • 23 Huang TF, Ouyang C, Teng CM. Rhodostomin, a snake venom peptide and its fragment inhibit platelet aggregation by acting as fibrinogen receptor antagonist, Abstract 141. 11th Int Congr on Thrombosis, Ljubljana, Yugoslavia 1990
    PubMedGoogle Scholar
  • 24 Garsky VM, Lumma PK, Freidinger RM, Pitzenberger SM, Randall WC, Veber DF, Gould RJ, Friedman PA. Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs. Proc Natl Acad Sci USA 1989; 86: 4022-4026
    CrossrefPubMedGoogle Scholar
  • 25 Teng CM, Ma YH. Properties of a potent platelet aggregation inhibitor from Echis carinatus snake venom. In: Animal Venoms and Hemostasis Pirkle H, Markland FS. (eds). Marcel Dekker Inc.,; New York: 1988: 399-409
  • 26 Ouyang C, Teng CM. Fibrinogenolytic enzymes of Trimeresurus venom. Biochim Biophys Acta 1976; 420: 298-308
    CrossrefPubMedGoogle Scholar
  • 27 Ouyang C, Teng CM, Chen YC. Properties of fibrinogen degradation products produced by Α- and Β-fibrinogenases of Trimeresurus mucrosquamatus snake venom. Toxicon 1979; 17: 121-126
    PubMedGoogle Scholar
  • 28 Ouyang C, Hwang LJ, Huang TF. Inhibition of rabbit platelet aggregation by Α-fibrinogenases purified from Agkistrodon rhodos-toma (Malayan pit viper) snake venom. J Formosan Med Assoc 1985; 84: 1196-1206
    PubMedGoogle Scholar
  • 29 Chen RH, Chen YC. Isolation of an acidic phospholipase A2 from the venom of Agkistrodon acutus (five pace snake) and its effect on platelet aggregation. Toxicon 1989; 27: 675-682
    CrossrefPubMedGoogle Scholar
  • 30 Chen YC, Maraganore JM, Reardon I, Heinrikson KL. Characterization of the structure and function of three phospholipases A2 from the venom of Agkistrodon halys pallas. Toxicon 1987; 25: 401-409
    CrossrefPubMedGoogle Scholar
  • 31 Kini RM, Evans HJ. Correlation between the enzymatic activity, anticoagulant and antiplatelet effects of phospholipase A2 isoenzymes from Naja nigricollis venom. Thromb Haemostas 1988; 60: 170-173
    PubMedGoogle Scholar
  • 32 Boffa GA, Boffa MC, Winchenne JJ. A phospholipase A2 with anticoagulant activity. I. Isolation from Viper a berus venom and properties. Biochim Biophys Acta 1976; 429: 828-838
    CrossrefPubMedGoogle Scholar
  • 33 Boffa MC, Boffa GA. A phospholipase A2 with anticoagulant activity. II. Inhibition of the phospholipid activity in coagulation. Biochim Biophys Acta 1976; 429: 839-852
    CrossrefPubMedGoogle Scholar
  • 34 Teng CM, Chen YH, Ouyang C. Effect of Russel’s viper venom phospholipase A on blood coagulation and platelet aggregation. Semin Thromb Hemostas 1985; 11: 369-374
    PubMedGoogle Scholar
  • 35 Ouyang C, Huang TF. Effect of the purified phospholipases A2 from snake and bee venoms on rabbit platelet function. Toxicon 1984; 22: 705-718
    CrossrefPubMedGoogle Scholar
  • 36 Huang TF, Ouyang C. Action mechanism of the potent platelet aggregation inhibitor from Trimeresurus gramineus snake venom. Thromb Res 1984; 33: 124-138
    PubMedGoogle Scholar
  • 37 Ouyang C, Huang TF. Platelet aggregation inhibitor from Trimeresurus gramineus snake venom. Biochim Biophys Acta 1983; 757: 332-341
    CrossrefPubMedGoogle Scholar
  • 38 Huang TF, Yeh HI, Ouyang C. Mechanism of action of the platelet aggregation inhibitor purified from Agkistrodon halys (Mamushi) snake venom. Toxicon 1984; 22: 243-251
    CrossrefPubMedGoogle Scholar
  • 39 Teng CM, Kuo YP, Lee LG, Ouyang C. Effect of cobra venom phospholipase A2 on platelet aggregation in comparison with those produced by arachidonic acid and lysophosphatidylcholine. Thromb Res 1986; 44: 875-886
    CrossrefPubMedGoogle Scholar
  • 40 Teng CM, Chen YH, Ouyang C. Biphasic effect on platelet aggregation by phospholipase A purified from Vipera russellii snake venom. Biochim Biophys Acta 1984; 772: 393-402
    CrossrefPubMedGoogle Scholar
  • 41 Li YS, Liu KF, Wang QC, Ran YL, Tue GC. A platelet function inhibitor purified from Vipera russelli siamensis (Smith) snake venom. Toxicon 1985; 23: 895-903
    CrossrefPubMedGoogle Scholar
  • 42 Boffa MC, Boffa GA. Correlations between the enzymatic and factors active on blood coagulation and platelet aggregation from the venom of Vipera aspis. Biochim Biophys Acta 1974; 354: 275-290
    CrossrefPubMedGoogle Scholar
  • 43 Ouyang C, Huang TF. Inhibition of platelet aggregation by 5′-nucleotidase purified from Trimeresurus gramineus snake venom. Toxicon 1983; 21: 491-501
    CrossrefPubMedGoogle Scholar
  • 44 Ouyang C, Huang TF. Platelet aggregation inhibitors from Agkistrodon acutus snake venom. Toxicon 1986; 24: 1099-1106
    CrossrefPubMedGoogle Scholar
  • 45 Smith SV, Brinkhous KU. Inventory of exogenous platelet-aggregating agents. In: Handbook of Natural Toxins, Volume 5, Reptile and Amphibian Venoms Tu AT. (ed). Marcel Dekker, Inc.; New York: (in press).
  • 46 Markland Jr. FS. Inventory of Α- and Β-fibrinogenases from snake venoms. Thromb Haemostas 1991; 65 (04) 438-443
    PubMedGoogle Scholar