Thrombotic Complications During L-Asparaginase Related to Protein C Deficiency?

Thromb Haemost 1985; 53(03): 443
DOI: 10.1055/s-0038-1665542

Letter to the Editor

Schattauer GmbH Stuttgart

E Vellenga

¹Department of Haematology, University Hospital, 9713 EZ Groningen, The Netherlands

,

A W Broekmans

²Department of Haematology, University of Leiden, The Netherlands

,

C Kluft

³The Gaubius Institute, Leiden, The Netherlands

References
1 Barbui T, Finazzi G, Vigano S, Mannucci PM. L-asparaginase lowers protein C antigen. Thromb Haemostas 1984; 52: 216
2 Mannucci PM, Vigano S. Deficiencies of protein C and inhibitor of blood coagulation. Lancet 1982; 2: 436-466
3 Bertina RM, Broekmans AW, Krommenhoek-van EsC, van Wijngaarden A. The use of a functional and immunological assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency. Thromb Haemostas 1984; 51: 1-5
4 Comp PC, Esmon CT. Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest 1981; 68: 1221-1228
5 Verheyen JH, Rijken DC, Brommer EJ P, Chang CT G. Measurement of tissue-type plasminogen activator activity, antigen and inhibition in plasma. Clinical aspects of fibrinolysis and thrombolysis. Jespersen J, Kluft C, Korsgaard O. (Eds) South Jutland University Press; Esbjers, Denmark: 1983. pp 121-131