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DOI: 10.1055/s-0038-1666860
Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk: Role in Cardiovascular Disease and Therapeutic Perspectives
Funding This work was partially supported by the Catholic University of the Sacred Heart, Rome, Italy [Grant R4124500186 LINEA D.1 2014 and Grant R4124500458 LINEA D.1 2016].Publication History
13 November 2017
22 May 2018
Publication Date:
10 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/201808/lookinside/thumbnails/10-1055-s-0038-1666860_170799-1.jpg)
Abstract
Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability. In this review, we will address the role of inflammasome in innate immunity and in the imbalance of adaptive immunity. We will discuss how this altered immune crosstalk is related to CAD onset and progression. We will also discuss how unravelling the key molecular mechanisms is of paramount importance in the development of therapeutic tools to delay the chronic progression and prevent the acute destabilization of atherosclerotic plaque.
Keywords
precision medicine - inflammasome - innate immunity - adaptive immunity - coronary artery disease - acute coronary syndromes* Daniela Pedicino and Ada Francesca Giglio have contributed equally.
** Filippo Crea and Giovanna Liuzzo have contributed equally.
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