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Thromb Haemost 1979; 42(02): 556-563
DOI: 10.1055/s-0038-1666893
DOI: 10.1055/s-0038-1666893
Original Article
Decreased Heparin Sensitivity of Cyclohexanedione-Modified Factor Xa
Further Information
Publication History
Received 21 June 1978
Accepted 28 August 1978
Publication Date:
23 August 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/197901/lookinside/thumbnails/10-1055-s-0038-1666893-1.jpg)
Summary
Modification of 12 arginine residues of bovine Factor Xa with 1,2-cyclohexanedione has resulted in a decrease in heparin sensitivity of the reaction between enzyme and antithrombin-III, whereas the antithrombin-III sensitivity of modified Factor Xa was only slightly affected. It is suggested that heparin accelerates the Factor Xa-antithrombin-III reaction by interacting with Factor Xa.
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