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Thromb Haemost 1979; 42(02): 596-602
DOI: 10.1055/s-0038-1666897
Original Article
Schattauer GmbH Stuttgart

Effect of Diuresis on Urokinase Excretion Rate

Osamu Matsuo
The Department of Physiology, Miyazaki Medical College, Miyazaki, Japan
,
Tomoko Kawaguchi
The Department of Physiology, Miyazaki Medical College, Miyazaki, Japan
,
Tadayoshi Kosugi
The Department of Physiology, Miyazaki Medical College, Miyazaki, Japan
,
Hisashi Mihara
The Department of Physiology, Miyazaki Medical College, Miyazaki, Japan
,
Takahiko Kimura
*   Special Research Fellow in Department of Physiology, Miyazaki Medical College, Miyazaki, Japan
› Author Affiliations
Further Information

Publication History

Received 25 July 1978

Accepted 28 August 1978

Publication Date:
23 August 2018 (online)

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Summary

UK excretion rate in the diuretic state was investigated in human and animal studies. Loading of water, beer or diuretics in man decreased the UK excretion rate as urine flow increased. A linear relation between UK excretion rate and urine specific gravity was observed. Simultaneous loading of water and exercise suppressed the decrease in UK excretion rate and the increase in urine flow. In animal studies, a null value for UK excretion rate was observed as a result of giving physiological saline and/or furosemide, and a remarkable increase in urine flow was induced. These results clearly suggest the existence of a relation between renal function and UK excretion rate.

 

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