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Thromb Haemost 1979; 42(02): 603-610
DOI: 10.1055/s-0038-1666898
DOI: 10.1055/s-0038-1666898
Original Article
The Effect of Agents which Modify Platelet Behaviour and of Magnesium Ions on Thrombus Formation In Vivo
Weitere Informationen
Publikationsverlauf
Received 26. Juni 1978
Accepted 03. November 1978
Publikationsdatum:
23. August 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/197901/lookinside/thumbnails/10-1055-s-0038-1666898-1.jpg)
Summary
The ability of potential anti-thrombotic agents to modify platelet-thrombus formation in injured cerebral arteries in the rabbit was tested. Low doses of heparin were without effect, while higher doses produced variable suppression of white body formation but at the expense of bleeding. Aspirin did not inhibit white body formation but another non-steroid anti-inflammatory agent, flurbiprofen was able to do so, as was the anti-gout agent, sulphinpyrazone. Magnesium salts both topically and parenterally, suppressed thrombus formation and increased the concentration of ADP which was required to initiate thrombus production at minor injury sites.
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References
- 1 Acland R. 1972; Prevention of thrombosis in microvascular surgery by the use of magnesium sulphate. British Journal of Plastic Surgery 25: 292
- 2 Anturane Reinfarction Trial Research Group. 1978 Sulphinpyrazone in the prevention of cardiac death after myocardial infarction. New England Journal of Medicine. 298. 289
- 3 Arfors K-E, Bergqvist D, Tangen O. 1975; The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits. Acta. Chirurgica Scandinavica 141: 40
- 4 Bergqvist D, Arfors K-E. 1976; Microvascular haemostasis and the effect of local stimulation and inhibition of platelet function. An experimental study in rabbits Thrombosis and Haemostasis 36: 133
- 5 Emmons PR, Harrison MJ G, Honour AJ, Mitchell JR A. 1965; Effect of a pyrimido- pyrimidine derivative on thrombus formation in the rabbit. Nature 208: 255
- 6 Emmons PR, Hampton JR, Harrison MJ G, Honour AJ, Mitchell JR A. 1967; Effect of prostaglandin El on platelet behaviour in vitro and in vivo. British Medical Journal 2: 468
- 7 Grollman A, Slaughter D. 1947. Pharmacology and Therapeutics. Churchill; London:
- 8 Gurewich V, Lipinski B. 1976; Evaluation of antithrombotic properties of suloctidil in comparison with aspirin and dipyridamole. Thrombosis Research 9: 101
- 9 Hampton JR, Harrison MJ G, Honour AJ, Mitchell JR A, Prichard JS. 1972; Assessment of anti-thrombotic agents: effects of dipyridamole analogues on platelet behaviour. Cardiovascular Research 6: 696
- 10 Heptinstall S. 1976; The use of a chelating ion-exchange resin to evaluate the effects of the extracellular calcium concentration on adenosine diphosphate induced aggregation of human blood platelets. Thrombosis and Haemostasis 36: 208
- 11 Heptinstall S, Mulley GP. 1977; Adenosine diphosphate induced platelet aggregation and release reaction in heparinised platelet rich plasma and the influence of added citrate. British Journal of Haematology 36: 565
- 12 Honour AJ, Mitchell JR A. 1964; Platelet clumping in injured vessels. British Journal of Experimental Pathology 45: 75
- 13 Honour AJ, Ross-Russell RW. 1962; Experimental platelet embolism. British Journal of Experimental Pathology 43: 350
- 14 Honour AJ, Hockaday TD R, Mann JI. 1977; The synergistic effect of aspirin and dipyridamole upon platelet thrombi in living blood vessels. British Journal of Experimental Pathology 58: 268
- 15 Innocenti IR-D, Poggi A, De Gaetano G. 1974; Platelet aggregation and haemolysis induced in rats by intravenous infusion of ADP effect of potentially antithrombotic drugs. Scandinavian Journal of Haematology 13: 331
- 16 Macfarlane DE, Walsh PN, Mills DC B, Holmsen H, Day HJ. 1975; The role of thrombin in ADP-induced platelet aggregation and release; a critical appraisal. British Journal of Haematology 30: 457
- 17 Mason RG, Wolf RH, Zucker WH, Shinoda BA, Mohammad SF. 1976; a Effects of antithrombotic agents evaluated in a non-human primate vascular shunt model. American Journal of Pathology 83: 557
- 18 Mason RG, Wolf RH, Zucker WH, Shinoda BA. 1976; b Dynamics of thrombus formation on an artificial surface in vivo. American Journal of Pathology 82: 445
- 19 Mielke CH, De Leval M, Hill JD, Macur MF, Gerbode F. 1973; Drug influence on platelet loss during extracorporeal circulation. Journal of Thoracic Cardiovascular Surgery 66: 845
- 20 Mitchell JR A. 1969; Anticoagulant Therapy in Ischaemic Heart Disease. Abstracts of World Medicine 43: 249
- 21 Mitchell JR A. 1978. Prevention of Thrombosis. In Weatherall DJ. (ed.) Advanced Medicine, Pitman London:
- 22 Moncada S, Gryglewski R, Bunting S, Vane JR. 1976; An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663
- 23 Niewiarowski S, Lukasiewicz H, Nath N, Sha AT. 1975; Inhibition of human platelet aggregation by dipyridamole and two related compounds and its modification by acid glycoproteins of human plasma. Journal of Laboratory and Clinical Medicine 86: 64
- 24 Nishizawa EE, Wynalda DJ, Snydam. Malony BA. 1973; Flurbiprofen, a new potent inhibitor of platelet aggregation. Thrombosis Research 3: 577
- 25 Packham MA, Mustard JF. 1977; Clinical Pharmacology of Platelets. Blood 50: 555
- 26 Poole JC F, French JE. 1961; Thrombosis. Journal of Atherosclerosis Research 1: 251
- 27 Sheppard BL. 1972; The effect of acetylsalicylic acid on platelet adhesion in the injured abdominal aorta. Quarterly Journal of Experimental Physiology 57: 319
- 28 Verstraete M. 1976; Are agents affecting platelet functions clinically useful. American Journal of Medicine 61: 897
- 29 Wessler S, Yin ET. 1973; Theory and practice of minidose heparin in surgical patients. A status report. Circulation 47: 671
- 30 Wharton-Jones T. 1851; On the state of the Blood and the blood vessels in inflammation. Guy’s Hospital Reports, Series 2 7: 1