Creatine Phosphate in Rat Platelets Decreased by ADP or Thrombin

Sachiko Shibata

doi:10.1055/s-0038-1666901

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1979; 42(02): 626-630
DOI: 10.1055/s-0038-1666901

Original Article

Schattauer GmbH Stuttgart

Creatine Phosphate in Rat Platelets Decreased by ADP or Thrombin

Authors

Sachiko Shibata

The Radioisotope Research Laboratory, School of Pharmaceutical Sciences, Kitasato University, Tokyo 108, Japan

Abstract

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Summary

ADP or thrombin caused a transient change in creatine phosphate (CP) content of rat platelets. At 25°C the CP content decreased most 30 sec after the addition of ADP or thrombin and recovered thereafter. ATP or AMP was without effect. The rat platelets aggregated at 25° C by ADP or thrombin, but the changes in CP content by these inducers were also observed in the platelet preparations unable to aggregate by the lack of Ca²⁺. A persistent chilling made the platelets lose their ability to change CP content. It was suggested that in rat platelets CP is consumed in the early stage of the response to the aggregating agents, presumably donating the energy for shape change.

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References

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