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DOI: 10.1055/s-0038-1666902
Platelet Aggregation Evoked In Vitro and In Vivo by Phosphatidic Acids and Lysoderivatives: Identity with Substances in Aged Serum (DAS)[*]
Publikationsverlauf
Received 02. September 1977
Accepted 30. November 1977
Publikationsdatum:
23. August 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/197901/lookinside/thumbnails/10-1055-s-0038-1666902-1.jpg)
Summary
In serum incubated at 36° C for 18-24 hours a factor (DAS) develops which on intravenous injection into cats evokes platelet aggregation followed by an increase in pulmonary vascular resistance (PVR). This change in PVR is mediated via the platelets since it significantly correlates with the preinjection platelet count. There is evidence that phosphatidic acids (PA) and lysophosphatidic acids (LPA) are the active components of DAS. Investigations performed on platelet-rich plasma from man, cat, pig, dog, rabbit, guinea pig, and rat demonstrate that only human and feline platelets exposed to PA or to LPA are aggregated. Feline platelets are more sensitive to either compound than are the platelets from men; however, human platelets exhibit two exceptional properties, a) the sensitivity rapidly declines with time, b) pretreatment with subthreshold concentrations of LPA or PA induces a specific tachyphylaxis.
* Partially presented at the 1st Florence Conference on Thrombosis and Haemostasis, May 1977.
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References
- 1 Benner KU, Schumacher KA, Classen HG. 1974; Platelet aggregation induced by DAS in vitro: some investigation on its mode of action. Thrombosis et Diathesis Haemorrhagica 23: 354
- 2 Benner KU, Schumacher KA, Classen HG. 1975; Platelet aggregation induced by anaphylatoxin and its inhibition. Arzneim.-Forsch 25: 1635
- 3 Born GV R. 1962; Quantitative investigations into the aggregation of blood platelets. Journal of Physiology 162: 67
- 4 Brecher G, Cronkite EP. 1950; Morphology and enumeration of human blood platelets. Journal of d. Applied Physiology 3: 365
- 5 Hagedorn M, Schumacher KA, Sugihara H, Mtitermayer Chr. 1974; Morphological study of circulatory failure induced by a platelet aggregating factor DAS Beitr. Path 152: 105
- 6 Marquardt P. 1961; Zur pyrogenen Wirkung von DAS (Frühgift). Helvetia Physiologia Acta 19 C 29
- 7 Schumacher KA, Classen HH. 1972; Platelet aggregation and increased pulmonary vascular resistance in cats induced by DAS and ADP. Naunyn-Schmiedeberg’s Archives of Pharmacology 275: 373
- 8 Schumacher KA, Classen HG, Hagedorn M, Benner KU, Spath M, Mtitermayer Chr. 1974; Effect of anaphylatoxin plasma in cats: hemodynamic changes induced by platelet aggregation. Arzneim.-Forsch 24: 122
- 9 Wadsworth A, Maltaner F, Maltaner E. 1927; A study of coagulation of the blood; the chemical reactions underlying the process. American Journal of Physiology 80: 502