RSS-Feed abonnieren
DOI: 10.1055/s-0038-1666915
Evaluation of the In Vitro Detection of the Hypercoagulable State Using the Thrombin Generation Test and Plasma Clot Impedance Test
Publikationsverlauf
Received 18. Mai 1978
Accepted 31. Januar 1979
Publikationsdatum:
23. August 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/197901/lookinside/thumbnails/10-1055-s-0038-1666915-1.jpg)
Summary
This study reports the correlation of the thrombin generation test and the plasma clot impedance test with clinical evidence of hypercoagulability. Thrombin generation is increased and the rate of change of plasma from a liquid to a gel (clot impedance) is increased in situations where the risk of thrombosis is increased.
These situations include increasing clinical signs and/or symptoms of thromboembolism, positive lung scans, postoperative total hip replacement, patients over 40 years old, low serum antithrombin III, thrombocytosis, transient cerebral ischemia, and positive isotope venogram for thrombosis. The two tests failed to indicate a significant effect of antiplatelet drugs on the hypercoagulable state.
This study shows that the thrombin generation and plasma clot impedance tests are practical, rapid and useful tests for the detection and monitoring of the hypercoagulable state.
-
References
- 1 Adar R, Salzman EW. 1975; Treatment of thrombosis of the veins of the lower extremities. New England Journal of Medicine 292: 348
- 2 Cervantes FD, Schneiderman LJ. 1975; Anticoagulants in cerebrovascular disease. Archives of Internal Medicine 135: 875
- 3 Coon WW, Willis PW, Keller JB. 1973; Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation 48: 839
- 4 Genton G, Gent M, Hirsh J, Harker LA. 1975; Platelet inhibiting drugs in the prevention of clinical thrombotic disease. New England Journal of Medicine 293, 1174, 1236 2196
- 5 Hartsuck JM, Greenfield LJ. 1973; Postoperative thromboembolism. Archives of Surgery 107: 733
- 6 Hume M, Turner RH, Kuriakose TX, Surprenant J. 1976; Venous thrombosis after total hip replacement. The Journal of Bone and Joint Surgery 58-A 933
- 7 Innerfield I, Goldfischer JD, Reicherreiss H, Greenberg J. 1976; Serum antithrombin in coronary artery disease. American Journal of Clinical Pathology 65: 64
- 8 Kakkar VV, Corrigan TP, Fossard DP. 1975; Prevention of fatal postoperative pulmonary embolism by low doses of heparin. Lancet 45
- 9 Kistner RL, Ball JJ, Nordyke RA, Freeman GC. 1972; Incidence of pulmonary embolism in the course of thrombophlebitis of the lower extremities. American Journal of Surgery 124: 169
- 10 Modan B, Shani M, Schor S, Modan M. 1975; Reduction of hospital mortality from acute myocardial infarction by anticoagulant therapy. New England Journal of Medicine 292: 1360
- 11 Mustard JF. 1969; Platelets in thrombosis: Mechanisms and therapy. Hospital practice 46
- 12 Pessim MS, Dunean GW, Mohr TP, Posranzer DC. 1977; Clinical + angiographic Features of Carotid transient ischaemic attacks New England Journal of Medicine. 296: 358
- 13 Roberts WC. 1973; Does thrombosis play a major role in the development of symptom producing atherosclerotic plaques. Circulation 48: 1161
- 14 Sagar S, Stamatakis JD, Higgins AF, Nairn D, Maffei FH, Thomas DP, Kakkar Vv. 1976; a Efficacy of low dose heparin in the prevention of extensive deep vein thrombosis in patients undergoing total hip replacement. Lancet 1151
- 15 Sagar S, Stamatakis JD, Thomas DP, Kakkar VV. 1976; b Oral contraceptives, antithrombin III activity, and post operative deep vein thrombosis. Lancet 509
- 16 Sevitt S, Gallagher N. 1960; Venous thrombosis and pulmonary embolus, a clinico- pathological study in injured and burned patients. British Journal of Surgery 48: 475
- 17 Shapiro S. 1975; Oral contraceptives in myocardial infarction. New England Journal of Medicine 293: 195
- 18 Sherry S. 1975; Low dose heparin prophylaxis for post operative venous thromboembolism. New England Journal of Medicine 293: 300
- 19 Smyrimis SM, Kolios AS. 1973; Deep vein thrombosis in surgical patients; A phlébographie study. Surgery 73: 692
- 20 Tonascia J, Gordis L, Schmerler H. 1975; Retrospective evidence favoring the use of anticoagulants for myocardial infarction. New England Journal of Medicine 292: 1362
- 21 Von Kaulla E, Droegmueller W, Aoki N, Von Kaulla K. 1971; Antithrombin III depression and thrombin generation acceleration in women taking oral contraceptives. American Journal of Obstetrics and Gynecology 109: 868
- 22 Von Kaulla KN, Ostendorf P, Von Kaulla E. 1975; The impedance machine: A new bedside blood coagulation recording device. Journal of Medicine 6: 73
- 23 Von Kaulla KN, Von Kaulla E. 1964; Thrombin generation in normal subjects and cardiac patients. Circulation Research 14: 436
- 24 Von Kaulla KN, Von Kaulla E. 1967; Antithrombin III and disease. American Journal of Clinical Pathology 48: 69
- 25 Zuck TF, Bergin JJ, Raymond JM. 1971; Implications of depressed antithrombin III activity associated with oral contraceptives. Surgery, Gynecology and Obstetrics 133: 609
- 26 Zuck TF, Bergin JJ. 1973; Thrombotic predisposition associated with oral contraceptives. Obstetrics and Gynecology 41: 427