The Impact of Sperm and Egg Donation on the Risk of Pregnancy Complications

Michal Fishel Bartal; Baha M. Sibai; Yossi Bart; Avi Shina; Shali Mazaki-Tovi; Irit Schushan Eisen; Israel Hendler; Micha Baum; Eyal Schiff

doi:10.1055/s-0038-1667029

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2019; 36(02): 205-211
DOI: 10.1055/s-0038-1667029

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Impact of Sperm and Egg Donation on the Risk of Pregnancy Complications

Michal Fishel Bartal

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Baha M. Sibai

²Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), Houston, Texas

,

Yossi Bart

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Avi Shina

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Shali Mazaki-Tovi

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Irit Schushan Eisen

³Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Israel Hendler

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Micha Baum^*

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

,

Eyal Schiff^*

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

› Institutsangaben

Abstract

Objective The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation.

Materials and Methods This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (SD) were included. Obstetrics and neonatal outcomes for pregnancies following single SD were compared with pregnancies following repeat SD from the same donor. In a secondary analysis, we compared pregnancy outcomes among three modes of assisted reproductive technology (intrauterine insemination [IUI-SD], in vitro fertilization [IVF-SD], and IVF sperm + egg donation [IVF-SD + ED]).

Results A total of 706 pregnant women met the inclusion criteria, 243 (34.4%) following the first SD and 463 (65.6%) following repeat donations. Compared with repeat SDs, single donation was not associated with higher rates of preterm delivery (12.8 vs. 12.7%, respectively, p = 0.99), preeclampsia (7.0 vs. 6.9%, p = 0.999), and intrauterine growth restriction (4.1 vs. 3.9%, p = 0.88). Pregnancies following IVF-SD + ED had increased risk for preeclampsia (adjusted odds ratio [AOR], 3.1; 95% confidence interval [CI], 1.5–6.6), preterm labor (AOR, 2.4; 95% CI, 1.1–5.4), and cesarean section (AOR, 2.1; 95% CI, 1.0–4.3) compared with IUI-SD and IVF-SD.

Conclusion The extent of donor sperm exposure did not correlate with obstetrics complications, but double gamete donation was associated with increased risk for preeclampsia, preterm labor, and cesarean section.

Keywords

sperm donation - intrauterine insemination - prenatal - egg donation

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Referenzen

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