RSS-Feed abonnieren
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1055/s-0038-1667313
Mismatch Negativity in Children: Reference Values
Publikationsverlauf
07. August 2017
02. Juni 2018
Publikationsdatum:
24. Oktober 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00025477/201902/lookinside/thumbnails/10-1055-s-0038-1667313_0725or-1.jpg)
Abstract
Introduction The Mismatch Negativity (MMN) auditory evoked potential evaluation is a promising procedure to assess objectively the ability of auditory discrimination.
Objective To characterize the latency and amplitude values of MMN in children with normal auditory thresholds and without auditory complaints.
Methods Children between 5 and 11 years old participated in the present study. All participants underwent acoustic immittance measurements and tonal and vocal audiometry. The MMN was recorded with the MASBE ATC Plus system (Contronic, Pelotas, RS, Brazil). The electrodes were fixed in Fz (active electrode), Fpz (ground electrode) and in M2 and M1 (references electrodes). The intensity used was 80 dBHL, the frequent stimulus was 1,000 Hz and the rare stimulus was 2,000 Hz. The stimuli were presented in both ears separately.
Results For the female group, the mean latencies and amplitude of MMN were 177.3 ms and 5.01 μV in the right ear (RE) and 182.4 ms and 5.39 μV in the left ear (LE). In the male group, the mean latencies were 194.4 ms in the RE and 183.6 ms in the LE, with an amplitude of 5.11 μV in the RE and 5.83 μV in the LE. There was no statistically significant difference between ears (p = 0.867 - latency and p = 0.178 - amplitude), age (p > 0.20) and the gender of the participants (p > 0.05).
Conclusion Using the described protocol, the mean latency value of MMN was 184.0 ms for RE and 182.9 ms for LE, and the amplitude was 5.05 μV and 5.56 μV for the left and right ears, respective.
-
References
- 1 Didoné DD, Garcia MV, Oppitz SJ. , et al. Potencial evocado auditivo P300 em adultos: valores de referência. Einstein (Sao Paulo) 2016; 14 (02) 208-2012
- 2 Melo Â, Biaggio EPV, Rechia IC, Sleifer P. Potenciais evocados auditivos corticais em neonatos nascidos a termo e pré-termo. CoDAS 2016; 28 (05) 491-496
- 3 Santos MAR, Munhoz MSL, Peixoto MAL, Haase VG, Rodrigues JL, Resende LM. Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla. Rev Bras Otorrinolaringol 2006; 72 (06) 800-807
- 4 Näätänen R, Paavilainen P, Rinne T, Alho K. The mismatch negativity (MMN) in basic research of central auditory processing: a review. Clin Neurophysiol 2007; 118 (12) 2544-2590
- 5 Näätänen R, Astikainen P, Ruusuvirta T, Huotilainen M. Automatic auditory intelligence: an expression of the sensory-cognitive core of cognitive processes. Brain Res Brain Res Rev 2010; 64 (01) 123-136
- 6 Brossi AB, Borba KC, Garcia CFD, Reis ACMB, Isaac ML. Verificação das respostas do mismatch negativity (MMN) em sujeitos adultos normais. Rev Bras Otorrinolaringol 2007; 73 (06) 793-802
- 7 Rocha-Muniz CN, Befi-Lopes DM, Schochat E. Mismatch negativity in children with specific language impairment and auditory processing disorder. Rev Bras Otorrinolaringol (Engl Ed) 2015; 81 (04) 408-415
- 8 Roggia SM. Mismatch Negativity. In: Boéchat EM, Menezes PL, Couto CM, Frizzo ACF, Scharlach RC, Anastásio ART. , Eds. Tratado de Audiologia. 2ª ed. São Paulo: Santos; 2015: 151-159
- 9 Sleifer P. Avaliação eletrofisiológica da audição em crianças. In: Cardoso MC. (Org.), Fonoaudiologia na infância: avaliação e tratamento, Rio de Janeiro: Revinter; 2015: 171-194
- 10 Romero ACL, Regacone SF, Lima DDB, Menezes PL, Frizzo ACF. Potenciais relacionados a eventos em pesquisa clínica: diretrizes para eliciar, gravar, e quantificar o MMN, P300 e N400. Audiol Commun Res 2015; 20 (02) VII-VIII
- 11 Cheng CH, Chan PS, Hsieh YW, Chen KF. A meta-analysis of mismatch negativity in children with attention deficit-hyperactivity disorders. Neurosci Lett 2016; 612: 132-137
- 12 Schwade LF, Didoné DD, Sleifer P. Auditory Evoked Potential Mismatch Negativity in Normal-Hearing Adults. Int Arch Otorhinolaryngol 2017; 21 (03) 232-238
- 13 Cheour M, Leppänen PHT, Kraus N. Mismatch negativity (MMN) as a tool for investigating auditory discrimination and sensory memory in infants and children. Clin Neurophysiol 2000; 111 (01) 4-16
- 14 Alho K, Sainio K, Sajaniemi N, Reinikainen K, Näätänen R. Event-related brain potential of human newborns to pitch change of an acoustic stimulus. Electroencephalogr Clin Neurophysiol 1990; 77 (02) 151-155
- 15 Datta H, Shafer VL, Morr ML, Kurtzberg D, Schwartz RG. Electrophysiological indices of discrimination of long-duration, phonetically similar vowels in children with typical and atypical language development. J Speech Lang Hear Res 2010; 53 (03) 757-777
- 16 Koravand A, Jutras B, Lassonde M. Auditory event related potentials in children with peripheral hearing loss. Clin Neurophysiol 2013; 124 (07) 1439-1447
- 17 Paul I, Bott C, Heim S, Wienbruch C, Elbert TR. Phonological but not auditory discrimination is impaired in dyslexia. Eur J Neurosci 2006; 24 (10) 2945-2953
- 18 Huotilainen M, Lovio R, Kujala T, Tommiska V, Karma K, Fellman V. Could audiovisual training be used to improve cognition in extremely low birth weight children?. Acta Paediatr 2011; 100 (11) 1489-1494
- 19 Soares AJC, Sanches SGG, Neves-Lobo IF, Carvallo RMM, Matas CG, Cárnio MS. Potenciais evocados auditivos de longa latência e processamento auditivo central em crianças com alterações de leitura e escrita: Dados preliminares. Int Arch Otorhinolaryngol 2011; 15 (04) 486-491
- 20 Zhang Y, Zhang L, Shu H. , et al. Universality of categorical perception deficit in developmental dyslexia: an investigation of Mandarin Chinese tones. J Child Psychol Psychiatry 2012; 53 (08) 874-882
- 21 Noordenbos MW, Segers E, Serniclaes W, Mitterer H, Verhoeven L. Neural evidence of allophonic perception in children at risk for dyslexia. Neuropsychologia 2012; 50 (08) 2010-2017
- 22 Chobert J, François C, Habib M, Besson M. Deficit in the preattentive processing of syllabic duration and VOT in children with dyslexia. Neuropsychologia 2012; 50 (08) 2044-2055
- 23 van Zuijen TL, Plakas A, Maassen BA, Maurits NM, van der Leij A. Infant ERPs separate children at risk of dyslexia who become good readers from those who become poor readers. Dev Sci 2013; 16 (04) 554-563
- 24 Žarić G, Fraga González G, Tijms J, van der Molen MW, Blomert L, Bonte M. Reduced neural integration of letters and speech sounds in dyslexic children scales with individual differences in reading fluency. PLoS One 2014; 9 (10) e110337
- 25 Kaganovich N, Wray AH, Weber-Fox C. Non-linguistic auditory processing and working memory update in pre-school children who stutter: an electrophysiological study. Dev Neuropsychol 2010; 35 (06) 712-736
- 26 Holopainen IE, Korpilahti P, Juottonen K, Lang H, Sillanpää M. Attenuated auditory event-related potential (mismatch negativity) in children with developmental dysphasia. Neuropediatrics 1997; 28 (05) 253-256
- 27 Northens JL, Downs MP. . Audição e perda auditiva em crianças, 5 ed, In: Audição na Infância. Guanabara Koogan; 2005: 14
- 28 Jerger J. Clinical experience with impedance audiometry. Arch Otolaryngol 1970; 92 (04) 311-324
- 29 Uwer R, von Suchodoletz W. Stability of mismatch negativities in children. Clin Neurophysiol 2000; 111 (01) 45-52
- 30 Romero ACL, Capellini SA, Frizzo AC. Cognitive potential of children with attention deficit and hyperactivity disorder. Rev Bras Otorrinolaringol (Engl Ed) 2013; 79 (05) 609-615
- 31 Haapala S, Niemitalo-Haapola E, Raappana A. , et al. Effects of recurrent acute otitis media on cortical speech-sound processing in 2-year old children. Ear Hear 2014; 35 (03) e75-e83
- 32 Lepistö T, Soininen M, Ceponiene R, Almqvist F, Näätänen R, Aronen ET. Auditory event-related potential indices of increased distractibility in children with major depression. Clin Neurophysiol 2004; 115 (03) 620-627
- 33 Jansson-Verkasalo E, Ceponiene R, Valkama M. , et al. Deficient speech-sound processing, as shown by the electrophysiologic brain mismatch negativity response, and naming ability in prematurely born children. Neurosci Lett 2003; 348 (01) 5-8
- 34 Kathmann N, Frodl-Bauch T, Hegerl U. Stability of the mismatch negativity under different stimulus and attention conditions. Clin Neurophysiol 1999; 110 (02) 317-323
- 35 Yang FF, McPherson B, Shu H, Xiao Y. Central auditory nervous system dysfunction in infants with non-syndromic cleft lip and/or palate. Int J Pediatr Otorhinolaryngol 2012; 76 (01) 82-89
- 36 Gomot M, Blanc R, Clery H, Roux S, Barthelemy C, Bruneau N. Candidate electrophysiological endophenotypes of hyper-reactivity to change in autism. J Autism Dev Disord 2011; 41 (06) 705-714
- 37 Bar-Haim Y, Marshall PJ, Fox NA, Schorr EA, Gordon-Salant S. Mismatch negativity in socially withdrawn children. Biol Psychiatry 2003; 54 (01) 17-24
- 38 Ceponiene R, Haapanen ML, Ranta R, Näätänen R, Hukki J. Auditory sensory impairment in children with oral clefts as indexed by auditory event-related potentials. J Craniofac Surg 2002; 13 (04) 554-566 , discussion 567
- 39 Bishop DVM, Hardiman MJ, Barry JG. Lower-frequency event-related desynchronization: a signature of late mismatch responses to sounds, which is reduced or absent in children with specific language impairment. J Neurosci 2010; 30 (46) 15578-15584
- 40 Halliday LF, Barry JG, Hardiman MJ, Bishop DVM. Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study. J Neurodev Disord 2014; 6 (01) 21
- 41 Bruggemann JM, Stockill HV, Lenroot RK, Laurens KR. Mismatch negativity (MMN) and sensory auditory processing in children aged 9-12 years presenting with putative antecedents of schizophrenia. Int J Psychophysiol 2013; 89 (03) 374-380
- 42 Gução ACB. Efeito da variação de frequência e duração do estímulo no registro do P300 e MMN [dissertação]. São Paulo, Universidade Estadual Paulista: Faculdade de Filosofia e Ciências de Marília; 2014:28–31
- 43 Korpilahti P, Krause CM, Holopainen I, Lang AH. Early and late mismatch negativity elicited by words and speech-like stimuli in children. Brain Lang 2001; 76 (03) 332-339
- 44 Roggia SM, Colares NT. O mismatch negativity em pacientes com distúrbios do processamento auditivo (central). Rev Bras Otorrinolaringol 2008; 74 (05) 705-711
- 45 Sussman E, Ceponiene R, Shestakova A, Näätänen R, Winkler I. Auditory stream segregation processes operate similarly in school-aged children and adults. Hear Res 2001; 153 (1-2): 108-114
- 46 Holdefer L. Análise da latência e amplitude dos potenciais evocados auditivos relacionados a eventos Mismatch Negativity em orelhas com e sem zumbido. [tese de doutorado]. Brasília: Universidade de Brasília; 2014
- 47 Duncan CC, Barry RJ, Connolly JF. , et al. Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clin Neurophysiol 2009; 120 (11) 1883-1908
- 48 Jaramillo M, Paavilainen P, Näätänen R. Mismatch negativity and behavioural discrimination in humans as a function of the magnitude of change in sound duration. Neurosci Lett 2000; 290 (02) 101-104
- 49 Lindín M, Correa K, Zurrón M, Díaz F. Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment. Front Aging Neurosci 2013; 5: 79
- 50 Buranelli G, Barbosa MB, Garcia CFD. , et al. Verificação das respostas do Mismatch Negativity (MMN) em sujeitos idosos. Rev Bras Otorrinolaringol (Engl Ed) 2009; 75 (06) 831-838
- 51 Melo A, Sleifer P, Rechia IC, Biaggio EPV. Potencial evocado auditivo cortical em neonates a termo e pré-termo: gênero e indicadores de risco para deficiência auditiva. Audiol Commun Res 2016; 21: 1-7
- 52 Barrett KA, Fulfs JM. Effect of gender on the mismatch negativity auditory evoked potential. J Am Acad Audiol 1998; 9 (06) 444-451