Vaccinations for Anal Squamous Cancer: Current and Emerging Therapies

John Berry; Sean C. Glasgow

doi:10.1055/s-0038-1668101

Clinics in Colon and Rectal Surgery, Table of Contents

Clin Colon Rectal Surg 2018; 31(06): 321-327
DOI: 10.1055/s-0038-1668101

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Vaccinations for Anal Squamous Cancer: Current and Emerging Therapies

John Berry

¹Division of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri

,

Sean C. Glasgow

¹Division of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri

› Author Affiliations

Abstract

Human papillomavirus (HPV) infection is responsible for 4.3% of the global cancer burden. Since 2006, current HPV vaccines have reduced the prevalence of the virus in adolescent girls, reduced the prevalence of genital warts, and been proven to reduce the progression of anal intraepithelial neoplasia in men. Herein, we review the epidemiology, virology, and immunology behind the prophylactic HPV vaccines and current recommendations for its use. We also review future immune therapies being trialed for use against HPV-related cancers including anal cancer.

Keywords

anal cancer - human papillomavirus - anal intraepithelial neoplasia - anal squamous cell cancer

Full Text

References

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