Antibody-Associated Autoimmune Encephalitis and Epilepsies in Children

Tuhina Govil; Mitchel T. Williams

doi:10.1055/s-0038-1668588

Journal of Pediatric Epilepsy, Table of Contents

Journal of Pediatric Epilepsy 2018; 07(02): 040-044
DOI: 10.1055/s-0038-1668588

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Antibody-Associated Autoimmune Encephalitis and Epilepsies in Children

Tuhina Govil

¹Carman and Ann Adams Departments of Pediatrics and Neurology, Children's Hospital of Michigan, Detroit Medical Center Wayne State University School of Medicine, Detroit, Michigan, United States

,

Mitchel T. Williams

¹Carman and Ann Adams Departments of Pediatrics and Neurology, Children's Hospital of Michigan, Detroit Medical Center Wayne State University School of Medicine, Detroit, Michigan, United States

› Author Affiliations

Abstract

Autoimmune causes of epilepsy have become an increasingly recognized etiology, especially in treatment refractory cases. Over the past two decades, there has been an explosion of new biomarkers that have led to the identification of new syndromes. As the underlying pathophysiology is immune driven, their management and treatment are directed at the modulation of this abnormal immune response against self-antigens. These antibody-specific syndromes show variation between adult and pediatric populations. We focus this review article on those identified autoimmune encephalopathies and epilepsies and clinical differences between them as well as age-related variations that have been reported.

Keywords

autoimmune - epilepsy - encephalitis - pediatric

Full Text

References

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